Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cevimeline hydrochloride
Drug ID BADD_D00425
Description Cevimeline is a parasympathomimetic agent that act as an agonist at the muscarinic acetylcholine receptors M1 and M3. It is indicated by the Food and Drug Administration for the treatment of dry mouth associated with Sjögren's syndrome.
Indications and Usage For the treatment of symptoms of dry mouth in patients with Sjögren's Syndrome.
Marketing Status Prescription; Discontinued
ATC Code N07AX03
DrugBank ID DB00185
KEGG ID D00661
MeSH ID C059240
PubChem ID 123603
TTD Drug ID D0Q4CS
NDC Product Code 0054-0334; 46014-1002; 63395-201; 42973-228; 72166-012; 16571-657; 58159-087; 40032-999; 66406-0269; 43386-999
Synonyms cevimeline | 2-methyspiro(1,3-oxathiolane-5,3)quinuclidine | AF 102B, (trans)-isomer | AF-102B | AF 102B | AF102B | Evoxac | FKS 508 | FKS-508 | SNI 2011 | SNI-2011 | AF 102B, (cis-(+))-isomer | cevimeline hydrochloride
Chemical Information
Molecular Formula C10H18ClNOS
CAS Registry Number 107220-28-0
SMILES CC1OC2(CN3CCC2CC3)CS1.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Palpitations02.01.02.003--
Paraesthesia17.02.06.005--
Paralysis17.01.04.004--Not Available
Paranoia19.05.01.005--Not Available
Paronychia23.09.04.001; 11.01.12.001--
Parosmia22.04.03.007; 17.04.04.002--Not Available
Peptic ulcer07.04.07.001--Not Available
Pericarditis02.06.02.001--
Periodontal destruction11.01.04.008; 07.09.01.005--Not Available
Periorbital oedema23.04.01.002; 10.01.05.010; 06.08.03.017--
Peripheral ischaemia24.04.03.002--
Personality disorder19.05.02.002--Not Available
Pharyngitis11.01.13.003; 22.07.03.004; 07.05.07.004--
Phlebitis superficial24.05.03.004--Not Available
Photopsia17.17.01.006; 06.02.06.004--
Photosensitivity reaction23.03.09.003--
Plantar fasciitis15.03.03.002--Not Available
Platelet disorder01.08.03.001--Not Available
Pleural effusion22.05.02.002--
Pleurisy22.05.01.001--Not Available
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pollakiuria20.02.02.007--
Polyuria20.02.03.002--Not Available
Prostatic disorder21.04.01.001--Not Available
Pruritus23.03.12.001--
Pruritus genital21.10.01.002; 23.03.12.008--Not Available
Pulmonary congestion24.03.08.001; 22.01.03.002; 02.05.02.002--Not Available
Pulmonary embolism24.01.06.001; 22.06.02.001--Not Available
Pulmonary fibrosis22.01.02.006--
Purpura01.01.04.003; 24.07.06.005; 23.06.01.004--
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