Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cefuroxime
Drug ID BADD_D00407
Description Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, gonorrhea, and haemophilus.
Indications and Usage For the treatment of many different types of bacterial infections such as bronchitis, sinusitis, tonsillitis, ear infections, skin infections, gonorrhea, and urinary tract infections.
Marketing Status Prescription
ATC Code J01DC02; S01AA27
DrugBank ID DB01112
KEGG ID D00262
MeSH ID D002444
PubChem ID 41375
TTD Drug ID D0Y2IE
NDC Product Code 0143-9567; 0143-9977; 0143-9569; 0143-9979; 0143-9976; 0143-9568
Synonyms Cefuroxime | Cephuroxime | Zinacef | Ketocef
Chemical Information
Molecular Formula C16H16N4O8S
CAS Registry Number 55268-75-2
SMILES CON=C(C1=CC=CO1)C(=O)NC2C3N(C2=O)C(=C(CS3)COC(=O)N)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypokalaemia14.05.03.002--
Hypotension24.06.03.0020.008621%
Hypotonia17.05.02.002; 15.05.04.0080.000639%Not Available
Immune system disorder10.02.01.001--Not Available
Influenza22.07.02.001; 11.05.03.001--Not Available
Injection site pain12.07.03.011; 08.02.03.010--Not Available
Intraocular pressure increased13.07.04.0020.000639%Not Available
Irritability19.04.02.013; 08.01.03.011--
Jarisch-Herxheimer reaction10.02.01.002--Not Available
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.0040.000639%Not Available
Joint swelling15.01.02.004--Not Available
Kawasaki's disease11.07.01.007; 10.02.02.009; 24.05.01.0030.000958%Not Available
Lactic acidosis14.01.01.002--Not Available
Laryngeal oedema23.04.01.005; 22.04.02.001; 10.01.05.0030.000639%
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.008--
Leukocytosis01.02.01.0020.001597%
Leukopenia01.02.02.001--Not Available
Linear IgA disease23.03.01.015; 10.04.02.0060.002874%Not Available
Lip oedema07.05.04.004; 23.04.01.006; 10.01.05.0040.000639%Not Available
Lip swelling23.04.01.007; 10.01.05.005; 07.05.04.0050.001916%Not Available
Liver disorder09.01.08.001--Not Available
Local reaction08.01.03.012--Not Available
Loss of consciousness17.02.04.0040.005109%Not Available
Lymphadenitis01.09.01.0010.000958%Not Available
Macular degeneration06.09.03.0010.000958%Not Available
Macular oedema06.04.06.0050.019797%Not Available
Maculopathy06.09.03.0070.005428%Not Available
Malaise08.01.01.003--
Melaena24.07.02.013; 07.12.02.0040.000639%Not Available
Metabolic acidosis14.01.01.0030.000639%Not Available
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