ADReCS

Pharmaceutical Information

Drug Name	Cefuroxime
Drug ID	BADD_D00407
Description	Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, gonorrhea, and haemophilus.
Indications and Usage	For the treatment of many different types of bacterial infections such as bronchitis, sinusitis, tonsillitis, ear infections, skin infections, gonorrhea, and urinary tract infections.
Marketing Status	approved
ATC Code	J01DC02; S01AA27
DrugBank ID	DB01112
KEGG ID	D00262
MeSH ID	D002444
PubChem ID	41375
TTD Drug ID	D0Y2IE
NDC Product Code	0143-9567; 0143-9569; 0143-9976; 0143-9568; 0143-9977; 0143-9979
UNII	O1R9FJ93ED
Synonyms	Cefuroxime \| Cephuroxime \| Zinacef \| Ketocef

Chemical Information

Molecular Formula	C16H16N4O8S
CAS Registry Number	55268-75-2
SMILES	CON=C(C1=CC=CO1)C(=O)NC2C3N(C2=O)C(=C(CS3)COC(=O)N)C(=O)O
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Erythema multiforme	23.03.01.003; 10.01.03.015	-	-
Extravasation	08.01.03.008	0.000315%		Not Available
Eye inflammation	06.04.05.002	0.000715%		Not Available
Eye irritation	06.04.05.003	0.000315%		Not Available
Eye swelling	06.08.03.003	0.000701%		Not Available
Eyelid oedema	23.04.01.003; 10.01.05.001; 06.04.04.004	0.000529%		Not Available
Face oedema	10.01.05.002; 08.01.07.003; 23.04.01.004	0.000930%
Feeling cold	08.01.09.008	0.000143%		Not Available
Feeling hot	08.01.09.009	0.000458%		Not Available
Flatulence	07.01.04.002	0.000529%
Flushing	24.03.01.002; 23.06.05.003; 08.01.03.025	0.001102%
Foetal distress syndrome	18.03.02.003	0.000358%		Not Available
Frequent bowel movements	07.02.04.002	0.000458%		Not Available
Gastritis	07.08.02.001	0.000143%
Gastrointestinal disorder	07.11.01.001	-	-	Not Available
Gastrointestinal infection	11.01.07.012; 07.19.02.005	-	-	Not Available
Gastrointestinal pain	07.01.05.005	0.000486%
Generalised oedema	08.01.07.004; 14.05.06.007	0.000429%
Generalised tonic-clonic seizure	17.12.01.002	0.000143%		Not Available
Glaucoma	06.03.01.002	0.000143%
Groin pain	15.03.02.004	-	-	Not Available
Haematocrit decreased	13.01.05.001	-	-	Not Available
Haemoglobin	13.01.05.018	-	-	Not Available
Haemoglobin decreased	13.01.05.003	-	-	Not Available
Haemolysis	01.06.04.002	0.000143%
Haemolytic anaemia	01.06.03.002	0.000143%		Not Available
Haemoptysis	02.11.04.009; 24.07.01.006; 22.02.03.004	0.000143%		Not Available
Head discomfort	17.02.05.027	0.000143%		Not Available
Headache	17.14.01.001	-	-
Hepatic failure	09.01.03.002	0.000215%

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