Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ceftriaxone sodium
Drug ID BADD_D00406
Description Ceftriaxone is a broad-spectrum third-generation cephalosporin antibiotic.[A215582] It has a very long half-life compared to other cephalosporins and is high penetrable into the meninges[A215582], eyes[A215647], and inner ear[A215627]. Ceftriaxone has broader and stronger gram-negative coverage then first or second-generation cephalosporins, but worse activity against methicillin-susceptible S.aureus. Ceftriaxone is a commonly used antimicrobial due to its good activity against multi-drug resistant Enterobacteriaceae, its relatively safe adverse effect profile, and its long half-life which allows for the convenience of daily or twice-daily dosing.[A215582]
Indications and Usage For the treatment of the infections (respiratory, skin, soft tissue, UTI, ENT) caused by S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph
Marketing Status Prescription; Discontinued
ATC Code J01DD04
DrugBank ID DB01212
KEGG ID D00924
MeSH ID D002443
PubChem ID 9570985
TTD Drug ID D07ACT
NDC Product Code 50090-2444; 60505-6151; 50090-0944; 0409-7338; 0409-7335; 50090-3810; 67184-1007; 67184-1006; 50090-4978; 25021-108; 70518-3099; 50090-3838; 38779-2383; 0409-7332; 0781-3209; 71205-545; 67184-1008; 0409-7334; 60505-6152; 70518-2499; 70518-0168; 68071-4682; 50090-3447; 0781-3210; 67184-1005; 0781-3206; 0338-5003; 0781-3207; 0338-5002; 70518-2301; 50090-1875; 0409-7333; 60505-6149; 0781-3208; 0409-7337; 51065-004; 50090-4689; 0409-7336; 60505-6150; 60505-6148; 66288-6100
Synonyms Ceftriaxone | Ceftriaxon | Cefatriaxone | Ceftriaxone, Disodium Salt, Hemiheptahydrate | Ceftrex | Ceftriaxon Curamed | Ceftriaxon Hexal | Ceftriaxona Andreu | Ceftriaxona LDP Torlan | Ceftriaxone Irex | Ceftriaxone Sodium | Ceftriaxone Sodium, Anhydrous | Anhydrous Ceftriaxone Sodium | Lendacin | Longacef | Longaceph | Ro13-9904 | Ro13 9904 | Ro139904 | Ro-13-9904 | Ro 13-9904 | Ro 13 9904 | Ro 139904 | Rocephin | Rocefalin | Rocephine | Rocefin | Tacex | Terbac | Ceftriaxone, Disodium Salt | Benaxona | Cefaxona
Chemical Information
Molecular Formula C18H16N8Na2O7S3
CAS Registry Number 73384-59-5
SMILES CN1C(=NC(=O)C(=N1)[O-])SCC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)[O-] .[Na+].[Na+]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Flatulence07.01.04.002--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Glossitis07.14.01.001--Not Available
Glycosuria20.02.01.005--
Granulocytopenia01.02.03.003--Not Available
Haematuria20.02.01.006; 24.07.01.047--
Haemolytic anaemia01.06.03.002--Not Available
Headache17.14.01.001--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypersensitivity10.01.03.003--
Hypertonia17.05.02.001; 15.05.04.007--Not Available
Injection site pain12.07.03.011; 08.02.03.010--Not Available
Jaundice23.03.03.030; 01.06.04.004; 09.01.01.004--Not Available
Kernicterus18.04.04.005; 17.13.01.007; 09.01.01.012--Not Available
Leukocytosis01.02.01.002--
Leukopenia01.02.02.001--Not Available
Lymphocytosis01.02.01.003--Not Available
Lymphopenia01.02.02.002--Not Available
Monocytosis01.02.01.004--Not Available
Nausea07.01.07.001--
Nephrolithiasis20.04.01.002--
Nephropathy toxic20.05.03.002; 12.03.01.010--Not Available
Neutropenia01.02.03.004--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Oliguria20.01.03.004--Not Available
Pain08.01.08.004--
Palpitations02.01.02.003--
Pancreatitis07.18.01.001--
Phlebitis12.02.01.002; 24.05.03.001--
Prothrombin time prolonged13.01.02.012--Not Available
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