Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ceftizoxime
Drug ID BADD_D00402
Description A semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders.
Indications and Usage For the treatment of infections due to susceptible strains of microorganisms.
Marketing Status Discontinued
ATC Code J01DD07
DrugBank ID DB01332
KEGG ID D07658
MeSH ID D015296
PubChem ID 2655
TTD Drug ID D0Y7BD
NDC Product Code Not Available
Synonyms Ceftizoxime | Ceftizoxime Sodium | Sodium, Ceftizoxime | Ceftizoxime Monosodium Salt | Monosodium Salt, Ceftizoxime | Salt, Ceftizoxime Monosodium | SKF-88373 | SKF 88373 | SKF88373 | FR-13749 | FR 13749 | FR13749 | SK&F 88373-2 | SK&F 88373 2 | SK&F 883732 | Cefizox | FK749 | FK-749 | FK 749
Chemical Information
Molecular Formula C13H13N5O5S2
CAS Registry Number 68401-81-0
SMILES CON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=CCS3)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agranulocytosis01.02.03.001--Not Available
Alanine aminotransferase increased13.03.01.003--
Anaemia01.03.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Aplastic anaemia01.03.03.002--Not Available
Aspartate aminotransferase increased13.03.01.006--
Blood bilirubin increased13.03.01.008--
Blood creatinine increased13.13.01.004--
Blood lactate dehydrogenase increased13.04.02.002--
Blood urea increased13.13.01.006--Not Available
Body temperature increased13.15.01.001--Not Available
Cellulitis11.02.01.001; 23.09.01.001--Not Available
Death08.04.01.001--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Eosinophilia01.02.04.001--
Erythema multiforme23.03.01.003; 10.01.03.015--
Haemoglobin13.01.05.018--Not Available
Haemolytic anaemia01.06.03.002--Not Available
Hypersensitivity10.01.03.003--
Hypoaesthesia17.02.06.023--Not Available
Injection site pain12.07.03.011; 08.02.03.010--Not Available
Leukopenia01.02.02.001--Not Available
Nausea07.01.07.001--
Nephropathy toxic20.05.03.002; 12.03.01.010--Not Available
Neutropenia01.02.03.004--Not Available
Pain08.01.08.004--
Pancytopenia01.03.03.003--Not Available
Paraesthesia17.02.06.005--
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