| Drug Name |
Ceftazidime |
| Drug ID |
BADD_D00399 |
| Description |
Bacteria possess a cell wall comprising a glycopeptide polymer commonly known as peptidoglycan, which is synthesized and remodelled through the action of a family of enzymes known as "penicillin-binding proteins" (PBPs).[A232920] β-lactam antibiotics, including cephalosporins, are PBP inhibitors that, through inhibition of essential PBPs, result in impaired cell wall homeostasis, loss of cell integrity, and ultimately bacterial cell death.[A232920, A232925, A232930] Ceftazidime is a third-generation cephalosporin with broad-spectrum antibacterial activity, including against some treatment-resistant bacteria such as _Pseudomonas aeruginosa_.[L32935]
Ceftazidime was approved by the FDA on July 19, 1985, and is currently available either alone or in combination with the non-β-lactam β-lactamase inhibitor [avibactam] to treat a variety of bacterial infections.[L32935, L32940] |
| Indications and Usage |
For the treatment of patients with infections caused by susceptible strains of organisms in the following diseases: lower respiratory tract infections,skin and skin structure infections, urinary tract infections, bacterial septicemia, bone and joint infections, gynecologic infections, intra abdominal infections (including peritonitis), and central nervous system infections (including meningitis). |
| Marketing Status |
Prescription; Discontinued |
| ATC Code |
J01DD02 |
| DrugBank ID |
DB00438
|
| KEGG ID |
D00921
|
| MeSH ID |
D002442
|
| PubChem ID |
5481173
|
| TTD Drug ID |
D0PH5Z
|
| NDC Product Code |
25021-129; 0409-5084; 44567-236; 0409-5093; 10402-013; 0409-5082; 25021-128; 25021-127; 0264-3143; 0409-5092; 44567-237; 52946-0924; 0409-5086; 44567-235; 0264-3145 |
| Synonyms |
Ceftazidime | Fortaz | Fortum | Ceftazidime Pentahydrate | LY-139381 | LY 139381 | LY139381 | Tazidime | Ceftazidime Anhydrous | Pyridinium, 1-((7-(((2-amino-4-thiazolyl)((1-carboxy-1-methylethoxy)imino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-, inner salt, pentahydrate, (6R-(6alpha,7beta(Z)))- | GR-20263 | GR 20263 | GR20263 |
