Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cefotetan disodium
Drug ID BADD_D00392
Description A semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms.
Indications and Usage For prophylaxis and treatment of bacterial infections.
Marketing Status Prescription; Discontinued
ATC Code J01DC05
DrugBank ID DB01330
KEGG ID D02228
MeSH ID D015313
PubChem ID 53024
NDC Product Code 63323-385; 63323-386; 52946-0834
Synonyms Cefotetan | Apatef | Cefotetan Disodium | Disodium, Cefotetan | Cefotetan Disodium Salt | Disodium Salt, Cefotetan | Salt, Cefotetan Disodium | ICI-156834 | ICI 156834 | ICI156834 | YM-09330 | YM 09330 | YM09330 | Apacef | Ceftotan | Cefotan
Chemical Information
Molecular Formula C17H15N7Na2O8S4
CAS Registry Number 74356-00-6
SMILES CN1C(=NN=N1)SCC2=C(N3C(C(C3=O)(NC(=O)C4SC(=C(C(=O)N)C(=O)[O-])S4)OC)SC2)C(=O)[O- ].[Na+].[Na+]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Agranulocytosis01.02.03.001--Not Available
Alanine aminotransferase increased13.03.01.003--
Anaphylactic reaction24.06.03.006;
Anaphylactic shock24.06.02.004; Available
Aplastic anaemia01.03.03.002--Not Available
Aspartate aminotransferase increased13.03.01.006--
Blood bilirubin increased13.03.01.008--
Blood creatinine13.13.01.020--Not Available
Blood lactate dehydrogenase increased13.04.02.002--
Blood urea increased13.13.01.006--Not Available
Body temperature increased13.15.01.001--Not Available
Cholestasis09.01.01.001--Not Available
Complications of transplanted liver12.02.09.014; Available
Coombs direct test positive13.01.01.001--Not Available
Dermatitis23.03.04.002--Not Available
Discomfort08.01.08.003--Not Available
Erythema multiforme23.03.01.003;
Gastrointestinal pain07.01.05.005--
Haemoglobin13.01.05.018--Not Available
Haemolytic anaemia01.06.03.002--Not Available
Hepatic function abnormal09.01.02.001--Not Available
Injection site phlebitis24.05.03.003;; Available
Leukopenia01.02.02.001--Not Available
Nephropathy toxic12.03.01.010; Available
The 1th Page    1 2    Next   Last    Total 2 Pages