Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cefazolin
Drug ID BADD_D00382
Description A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
Indications and Usage Mainly used to treat bacterial infections of the skin. It can also be used to treat moderately severe bacterial infections involving the lung, bone, joint, stomach, blood, heart valve, and urinary tract. It is clinically effective against infections caused by staphylococci and streptococci species of Gram positive bacteria. May be used for surgical prophylaxis; if required metronidazole may be added to cover B. fragilis.
Marketing Status Prescription; Discontinued
ATC Code J01DB04
DrugBank ID DB01327
KEGG ID D02299
MeSH ID D002437
PubChem ID 33255
TTD Drug ID D09KDN
NDC Product Code 71872-7141; 0781-3450; 50090-4256; 44567-706; 72572-055; 71872-7027; 0143-9665; 0404-9833; 67184-1001; 0143-9924; 0143-9983; 60505-6142; 52584-923; 0143-9261; 44567-707; 0781-3452; 0781-3451; 70518-3047; 67184-0560; 17337-0300; 0143-9262; 0404-9834; 52584-087; 0143-9923; 60505-6231; 52584-924; 44567-120; 0404-9835; 72572-056; 0409-2585; 60505-6143; 44567-708
Synonyms Cefazolin | Cephazolin | Cefamedin | Cefamezine | Cephamezine | Gramaxin | Kefzol | Totacef | Ancef | Cefazolin Sodium | Sodium, Cefazolin | Sodium Cephazolin | Cephazolin, Sodium | Cephazolin Sodium | Sodium, Cephazolin
Chemical Information
Molecular Formula C14H14N8O4S3
CAS Registry Number 25953-19-9
SMILES CC1=NN=C(S1)SCC2=C(N3C(C(C3=O)NC(=O)CN4C=NN=N4)SC2)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypoprothrombinaemia01.01.01.0010.002235%Not Available
Hypotension24.06.03.0020.002874%
Hypovitaminosis14.12.01.0010.001065%Not Available
Hypoxia22.02.02.0030.000319%
Infection11.01.08.0020.000319%Not Available
Jaundice cholestatic09.01.01.0050.000213%Not Available
Laryngeal oedema23.04.01.005; 22.04.02.001; 10.01.05.0030.000532%
Leukocytosis01.02.01.0020.000213%
Leukopenia01.02.02.001--Not Available
Liver disorder09.01.08.001--Not Available
Local reaction08.01.03.012--Not Available
Loss of consciousness17.02.04.004--Not Available
Melaena24.07.02.013; 07.12.02.0040.000532%Not Available
Mouth ulceration07.05.06.004--Not Available
Myalgia15.05.02.001--
Myocardial infarction02.02.02.007; 24.04.04.009--
Myocardial ischaemia24.04.04.010; 02.02.02.0080.000056%Not Available
Nausea07.01.07.0010.002661%
Nephropathy20.05.03.001--Not Available
Nephropathy toxic12.03.01.010; 20.05.03.002--Not Available
Neutropenia01.02.03.0040.000639%Not Available
Oedema14.05.06.010; 08.01.07.0060.000213%Not Available
Oral candidiasis11.03.03.004; 07.05.07.001--Not Available
Oxygen saturation decreased13.02.01.0040.000319%Not Available
Pain08.01.08.004--
Pancytopenia01.03.03.003--Not Available
Paraesthesia17.02.06.0050.000426%
Pericardial haemorrhage24.07.01.013; 02.06.01.0030.000319%Not Available
Periorbital oedema23.04.01.002; 10.01.05.010; 06.08.03.0170.000319%
Pharyngeal oedema23.04.01.016; 22.04.05.003; 10.01.05.0160.000213%Not Available
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