Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cefazolin
Drug ID BADD_D00382
Description A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
Indications and Usage Mainly used to treat bacterial infections of the skin. It can also be used to treat moderately severe bacterial infections involving the lung, bone, joint, stomach, blood, heart valve, and urinary tract. It is clinically effective against infections caused by staphylococci and streptococci species of Gram positive bacteria. May be used for surgical prophylaxis; if required metronidazole may be added to cover B. fragilis.
Marketing Status approved
ATC Code J01DB04
DrugBank ID DB01327
KEGG ID D02299
MeSH ID D002437
PubChem ID 33255
TTD Drug ID D09KDN
NDC Product Code 0409-2585; 0143-9923; 0781-3451; 0404-9833; 72572-055; 60505-6231; 0781-3450; 60505-6142; 60505-6143; 71872-7027; 44567-707; 44567-840; 52584-924; 71205-679; 72572-056; 60505-6243; 17337-0300; 0143-9924; 44567-120; 52584-087; 60505-6244; 67184-0560; 67184-1001; 0404-9835; 44567-706; 52584-923; 70518-3047; 0143-9262; 0404-9834; 71872-7141; 0781-3452; 0143-9139; 0143-9140; 0143-9261; 0143-9665; 0143-9983; 44567-708
UNII IHS69L0Y4T
Synonyms Cefazolin | Cephazolin | Cefamedin | Cefamezine | Cephamezine | Gramaxin | Kefzol | Totacef | Ancef | Cefazolin Sodium | Sodium, Cefazolin | Sodium Cephazolin | Cephazolin, Sodium | Cephazolin Sodium | Sodium, Cephazolin
Chemical Information
Molecular Formula C14H14N8O4S3
CAS Registry Number 25953-19-9
SMILES CC1=NN=C(S1)SCC2=C(N3C(C(C3=O)NC(=O)CN4C=NN=N4)SC2)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hyponatraemia14.05.04.0020.000049%
Hypoprothrombinaemia01.01.01.0010.000583%Not Available
Hypotension24.06.03.0020.001142%
Hypovitaminosis14.12.01.0010.000219%Not Available
Hypoxia22.02.02.0030.000073%
Injection site reaction12.07.03.015; 08.02.03.014--
Jaundice cholestatic09.01.01.005--Not Available
Laryngeal oedema22.04.02.001; 10.01.05.003; 23.04.01.0050.000122%
Leukocytosis01.02.01.0020.000107%
Leukopenia01.02.02.0010.000049%Not Available
Lip swelling07.05.04.005; 23.04.01.007; 10.01.05.005--Not Available
Liver disorder09.01.08.001--Not Available
Local reaction08.01.03.012--Not Available
Loss of consciousness17.02.04.0040.000097%Not Available
Melaena24.07.02.013; 07.12.02.0040.000122%Not Available
Mouth ulceration07.05.06.004--Not Available
Myocardial ischaemia24.04.04.010; 02.02.02.0080.000049%Not Available
Nausea07.01.07.0010.000880%
Nephropathy20.05.03.001--Not Available
Nephropathy toxic20.05.03.002; 12.03.01.010--Not Available
Neurotoxicity12.03.01.011; 17.02.10.0020.000049%Not Available
Neutropenia01.02.03.0040.000170%Not Available
Oedema08.01.07.006; 14.05.06.0100.000049%Not Available
Oral candidiasis11.03.03.004; 07.05.07.001--Not Available
Pain08.01.08.004--
Pallor24.03.04.001; 23.03.03.031; 08.01.03.032--Not Available
Pancytopenia01.03.03.003--Not Available
Paraesthesia23.03.03.094; 17.02.06.0050.000180%
Pericardial haemorrhage24.07.01.013; 02.06.01.0030.000049%Not Available
Periorbital oedema23.04.01.002; 10.01.05.010; 06.08.03.0170.000073%
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