Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Caspofungin
Drug ID BADD_D00376
Description Caspofungin (brand name Cancidas worldwide) is an antifungal drug and the first member of a new drug class called the echinocandins, as coined by Merck & Co., Inc. It is typically administered intravenously. It shows activity against infections with Aspergillus and Candida, and works by inhibiting β(1,3)-D-Glucan of the fungal cell wall.
Indications and Usage For the treatment of esophageal candidiasis and invasive aspergillosis in patients who are refractory to or intolerant of other therapies.
Marketing Status Prescription
ATC Code J02AX04
DrugBank ID DB00520
KEGG ID D07626
MeSH ID D000077336
PubChem ID 2826718
TTD Drug ID D00ZCN
NDC Product Code Not Available
Synonyms Caspofungin | Cancidas | MK 0991 | MK-0991 | MK0991 | Caspofungin MSD | L 743,872 | L-743,872 | L743,872 | L-743872 | L743872 | L 743872 | Caspofungin Acetate
Chemical Information
Molecular Formula C52H88N10O15
CAS Registry Number 162808-62-0
SMILES CCC(C)CC(C)CCCCCCCCC(=O)NC1CC(C(NC(=O)C2C(CCN2C(=O)C(NC(=O)C(NC(=O)C3CC(CN3C(=O) C(NC1=O)C(C)O)O)C(C(C4=CC=C(C=C4)O)O)O)C(CCN)O)O)NCCN)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Infusion site swelling12.07.05.003; 08.02.05.002--Not Available
Infusion site phlebitis12.07.05.004; 08.02.05.003; 24.05.03.002--Not Available
Infusion site pruritus23.03.12.006; 12.07.05.005; 08.02.05.004--Not Available
Transaminases increased13.03.01.0150.001410%Not Available
Toxic skin eruption23.03.05.003; 10.01.01.0080.000705%Not Available
Ocular icterus06.08.03.009; 09.01.01.007; 01.06.04.007--Not Available
Viraemia11.01.11.0090.000705%
Angiopathy24.03.02.007--Not Available
Blood alkaline phosphatase increased13.04.02.0040.002115%
Infusion site rash08.02.05.017; 23.03.13.018; 12.07.05.017--Not Available
Drug resistance08.06.01.0050.000460%Not Available
Induration08.01.03.020--Not Available
Hepatic enzyme increased13.03.01.0190.000705%Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.027--
General symptom08.01.03.0210.000184%Not Available
Adenovirus infection11.05.09.0030.001057%Not Available
Cardiac disorder02.01.01.003--Not Available
Connective tissue disorder15.06.01.006--Not Available
Infestation23.09.05.001; 11.09.01.001--Not Available
Malnutrition14.03.02.004--Not Available
Mediastinal disorder22.09.03.001--Not Available
Mental disorder19.07.01.002--Not Available
Decreased appetite14.03.01.005; 08.01.09.0280.000705%
Feeling of body temperature change08.01.09.012--Not Available
Ill-defined disorder08.01.03.049--Not Available
Blood disorder01.05.01.004--Not Available
Autoimmune disorder10.04.04.003--
Hepatobiliary disease09.01.08.003--Not Available
Immunosuppressant drug level increased13.17.01.013--Not Available
Renal impairment20.01.03.010--Not Available
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