Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Carvedilol
Drug ID BADD_D00374
Description Carvedilol is a racemic mixture where the S(-) enantiomer is a beta adrenoceptor blocker and the R(+) enantiomer is both a beta and alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is advantageous in combination therapies as moderate doses of 2 drugs have a decreased incidence of adverse effects compared to high dose monotherapy in the treatment of moderate hypertension.[A182306] Carvedilol was granted FDA approval on 14 September 1995.[L7889]
Indications and Usage Carvedilol is indicated to treat mild to severe heart failure, left ventricular dysfunction after myocardial infarction with ventricular ejection fraction ≤40%, or hypertension.[L7889,L7892]
Marketing Status approved; investigational
ATC Code C07AG02
DrugBank ID DB01136
KEGG ID D00255
MeSH ID D000077261
PubChem ID 2585
TTD Drug ID D0W9LX
NDC Product Code 72888-034; 72888-035; 76385-112; 0904-6302; 55111-030; 65862-144; 68294-0005; 0093-7295; 43063-833; 50090-4171; 55154-5676; 55154-5678; 65862-143; 68788-7539; 68788-8177; 71335-0273; 71335-1813; 71335-1937; 76385-111; 76385-113; 0781-5223; 43063-126; 51079-771; 51079-932; 51407-040; 51655-034; 51655-943; 58118-0163; 60760-376; 63187-570; 63187-946; 68001-153; 68084-854; 68788-8151; 70518-3524; 71335-2026; 71335-2033; 65691-0087; 35356-512; 35356-526; 43353-838; 50090-4898; 51407-042; 53002-1572; 55154-7278; 60760-582; 61919-730; 61919-984; 63187-447; 0378-3631; 65841-617; 65841-618; 68001-151; 68071-3138; 68071-5275; 68788-9789; 71335-1128; 71335-1545; 55154-5677; 61919-219; 61919-728; 0378-3633; 0378-3634; 68001-152; 68071-2633; 68071-2773; 68788-7458; 68788-7603; 69784-141; 70934-753; 71335-2101; 71610-066; 72888-036; 0904-6300; 43353-832; 50090-2066; 51407-041; 51655-397; 51655-713; 60760-233; 63187-424; 63187-941; 68382-094; 68382-095; 68645-496; 69784-139; 70518-1826; 71610-132; 0615-8390; 0904-6301; 65862-142; 43353-874; 50090-2175; 51655-029; 51655-030; 55111-252; 60760-532; 68001-154; 68462-162; 71335-1457; 71335-1463; 71335-2023; 71610-067; 0615-8389; 72888-037; 52932-0726; 53104-7575; 64220-150; 0093-7296; 42708-072; 43063-129; 50090-1069; 50090-2079; 55111-253; 55111-255; 55154-5675; 68071-2780; 68382-092; 68462-163; 68462-165; 68645-350; 68788-8252; 69784-142; 70934-211; 71335-1407; 72189-372; 0615-8387; 0615-8388; 57451-1155; 65862-145; 65862-369; 0093-0051; 55154-6883; 63187-409; 68462-164; 68645-351; 68788-8231; 70518-1377; 70518-3640; 70934-910; 71610-062; 0781-5221; 66022-0120; 72761-004; 0093-0135; 43353-837; 50090-1856; 51655-033; 55154-6884; 61919-533; 63629-4060; 65841-616; 65841-619; 68071-2230; 68382-093; 68788-7910; 69784-140; 71335-1623; 71610-063; 76385-110; 0781-5224; 0904-6303; 42419-013; 43063-125; 51079-930; 51079-931; 51407-039; 55154-6885; 55700-819; 60760-494; 63187-131; 0378-3632; 67296-1497; 68788-9265; 70518-0356; 70518-0426; 70934-874; 71335-1533; 0781-5222; 47621-064; 0007-4142; 53002-1556; 53002-1573; 53002-1574; 55111-254
UNII 0K47UL67F2
Synonyms Carvedilol | Carvedilol Hydrochloride | Dilatrend | Querto | Eucardic | Carvedilol, (S)-isomer | Kredex | BM 14190 | BM-14190 | BM14190 | Carvedilol, (R)-isomer | Carvedilol, (+)-isomer | Carvedilol, (+) | Carvedilol, (+-)-isomer | Carvedilol, (-)-isomer | Carvedilol, (-) | Carvedilol, 14C-labeled | 14C-labeled Carvedilol | Carvedilol, 14C labeled | Coropres | Coreg
Chemical Information
Molecular Formula C24H26N2O4
CAS Registry Number 72956-09-3
SMILES COC1=CC=CC=C1OCCNCC(COC2=CC=CC3=C2C4=CC=CC=C4N3)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.0270.000052%
Cardiac disorder02.11.01.0030.000052%Not Available
Malnutrition14.03.02.004--Not Available
Mediastinal disorder22.09.03.001--Not Available
Poisoning12.03.01.004--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Erectile dysfunction21.03.01.007; 19.08.04.0010.000031%
Ill-defined disorder08.01.03.0490.000046%Not Available
Blood disorder01.05.01.004--Not Available
Disease recurrence08.01.03.0500.000070%Not Available
Drug intolerance08.06.01.0130.000280%Not Available
Psychotic disorder19.03.01.002--
Pulmonary toxicity22.01.02.007; 12.03.01.0130.000021%Not Available
Lymphocyte morphology abnormal13.01.06.015--Not Available
Renal impairment20.01.03.010--Not Available
Liver injury09.01.07.022; 12.01.17.012--Not Available
Low birth weight baby18.04.02.0030.000062%Not Available
Traumatic liver injury09.01.08.010; 12.01.17.027--Not Available
Acute kidney injury20.01.03.0160.000135%
Foetal growth restriction18.03.01.0020.000062%
Drug-induced liver injury12.03.01.044; 09.01.07.0230.000041%Not Available
Mouth swelling10.01.05.020; 07.05.04.007; 23.04.01.0200.000046%Not Available
Cardiac failure chronic02.05.01.0090.000031%Not Available
Coeliac disease14.02.01.007; 10.04.04.012; 07.17.01.0080.000052%Not Available
Transient tachypnoea of the newborn22.11.01.010; 18.04.09.0100.000021%Not Available
Live birth18.08.02.0070.000021%Not Available
Palatal oedema07.05.04.0080.000091%Not Available
Distributive shock24.06.02.0220.000041%Not Available
Unmasking of previously unidentified disease08.01.03.0800.000041%Not Available
Cardiac haemangioma benign02.10.01.003; 24.03.06.012; 16.02.01.0080.000021%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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