Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Carisoprodol
Drug ID BADD_D00370
Description Originally approved by the FDA in 1959 [FDA label], carisoprodol is a centrally acting muscle relaxant used in painful musculoskeletal conditions in conjunction with physical therapy and other medications [A176047]. This drug is available by itself in an oral tablet or combined with aspirin, or in a fixed-dose combination with both aspirin and codeine [FDA label, F4060, F4069]. In January 2012, this drug was classified as a Schedule IV substance under the controlled substances act in several US states due to alarming rates of abuse [A176062, A176077] despite having a low potential for abuse in addition to a low risk of dependence [L5074].
Indications and Usage For the relief of discomfort associated with acute, painful, musculoskeletal conditions.
Marketing Status Prescription; Discontinued
ATC Code M03BA02
DrugBank ID DB00395
KEGG ID D00768
MeSH ID D002328
PubChem ID 2576
TTD Drug ID D05PLH
NDC Product Code 70518-2800; 72789-019; 64980-380; 52286-0021; 50090-3232; 42543-700; 17337-0406; 50228-109; 76333-135; 63629-1168; 17381-080; 52536-682; 0037-2001; 0591-5513; 43353-102; 65862-158; 50090-5953; 68071-4610; 50090-5955; 62756-808; 71610-531; 72189-310; 77777-112; 50090-5214; 50090-4263; 71335-0693; 63187-786; 70518-3131; 63629-1167; 16571-780; 63629-8477; 71335-1203; 50090-4261; 55700-907; 50090-4746; 69584-111; 29033-207; 55700-954; 49452-1761; 29033-214; 55700-836; 60429-508; 0037-2250; 63629-1169; 55289-049; 70934-663; 60760-397; 71205-339; 63629-8478; 65862-260; 63629-8479; 71610-617; 63629-8202; 50090-5212; 65862-693; 58657-645; 60760-705; 55700-770; 16571-781; 50742-656; 66064-5001; 61919-878; 0143-1176; 63629-9144; 51525-5901; 52536-688; 45865-984; 63629-2416; 50090-3048; 71205-241; 71610-097; 51927-3169; 72789-016; 16714-510; 63629-9145; 50090-4744; 68071-5075; 43063-824; 71610-430; 70518-2618; 67296-1404; 64980-381; 72789-190; 72789-182; 72643-017; 63629-4707
Synonyms Carisoprodol | Isopropylmeprobamate | Isomeprobamate | Carisoprodate | Isobamate | Carisoma | Mio Relax | Soma | Vanadom | Soprodol | Somalgit
Chemical Information
Molecular Formula C12H24N2O4
CAS Registry Number 78-44-4
SMILES CCCC(C)(COC(=O)N)COC(=O)NC(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Irritability19.04.02.013; 08.01.03.011--
Lactic acidosis14.01.01.0020.000576%Not Available
Leukopenia01.02.02.001--Not Available
Loss of consciousness17.02.04.0040.000576%Not Available
Metabolic acidosis14.01.01.0030.000225%Not Available
Muscle spasms15.05.03.0040.000576%
Muscle twitching15.05.03.0050.001152%Not Available
Myocardial infarction24.04.04.009; 02.02.02.007--
Nausea07.01.07.001--
Nervous system disorder17.02.10.0010.000576%Not Available
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Pain08.01.08.0040.001728%
Pancytopenia01.03.03.003--Not Available
Paranoia19.05.01.0050.000864%Not Available
Pneumonia aspiration22.01.01.0050.000300%Not Available
Pulmonary embolism24.01.06.001; 22.06.02.0010.000864%Not Available
Pulmonary hypertension24.08.03.002; 22.06.01.0010.000150%
Pulmonary microemboli22.06.02.006; 24.01.06.0060.000576%Not Available
Rash23.03.13.001--Not Available
Respiratory arrest22.02.01.0090.001878%Not Available
Respiratory depression22.02.01.010; 17.02.05.0470.000864%Not Available
Respiratory distress22.02.01.0120.002016%Not Available
Seizure17.12.03.0010.001440%
Shock24.06.02.002--Not Available
Sinus tachycardia02.03.03.0100.001440%
Somnolence19.02.05.003; 17.02.04.006--
Status epilepticus17.12.03.0050.000576%Not Available
Suicide attempt19.12.01.0040.000300%
Syncope24.06.02.012; 17.02.04.008; 02.01.02.008--
Tachycardia02.03.02.0070.000225%Not Available
The 2th Page    First    Pre   2 3    Next   Last    Total 3 Pages