Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Carfilzomib
Drug ID BADD_D00367
Description Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combination therapy.[L39392]
Indications and Usage Carfilzomib is indicated for the treatment of patients with multiple myeloma who have received at least two prior therapies including bortezomib and an immunomodulatory agent and have demonstrated disease progression on or within 60 days of completion of the last therapy. Approval is based on response rate.
Marketing Status Prescription
ATC Code L01XG02
DrugBank ID DB08889
KEGG ID D08880
MeSH ID C524865
PubChem ID 11556711
NDC Product Code 50384-0180; 52076-6251; 76075-103; 50384-0230; 54893-0037; 76055-0035; 63552-009; 16436-0116; 63552-035; 50384-0260; 55111-985; 11722-059; 50384-0220; 50384-0210; 50384-0190; 67262-0010; 76075-102; 50384-0240; 42385-731; 76075-101
Synonyms carfilzomib | PR-171 | PR171 | Kyprolis
Chemical Information
Molecular Formula C40H57N5O7
CAS Registry Number 868540-17-4
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Aspartate aminotransferase increased13.03.01.006--
Asthenia08.01.01.0010.027707%Not Available
Asthma22.03.01.002; Available
Atrial fibrillation02.03.03.0020.005328%
Atrial flutter02.03.03.0030.001332%
Atrioventricular block02.03.01.0020.000533%Not Available
Atrioventricular block complete02.03.01.0030.000533%
Back disorder15.03.01.0140.001066%Not Available
Back pain15.03.04.0050.014386%
Blister12.01.06.002; Available
Blood albumin decreased13.09.01.0010.000533%Not Available
Blood bilirubin increased13.03.01.0080.001865%
Blood calcium increased13.11.01.0030.001598%Not Available
Blood creatinine abnormal13.13.01.0020.000799%Not Available
Blood creatinine increased13.13.01.0040.004795%
Blood glucose abnormal13.02.02.0080.000533%Not Available
Blood glucose decreased13.02.02.0010.000533%Not Available
Blood glucose increased13.02.02.0020.002131%Not Available
Blood immunoglobulin G increased13.06.05.0040.000533%Not Available
Blood lactate dehydrogenase increased13.04.02.0020.001598%
Blood magnesium decreased13.11.01.0080.000533%Not Available
Blood potassium decreased13.11.01.0100.002131%Not Available
Blood potassium increased13.11.01.0110.000799%Not Available
Blood pressure abnormal13.14.03.0010.001598%Not Available
Blood pressure decreased13.14.03.002--Not Available
Blood pressure fluctuation24.06.01.0020.000533%Not Available
Blood pressure increased13.14.03.0050.005328%Not Available
Blood sodium decreased13.11.01.0120.000533%Not Available
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