Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Carboprost tromethamine
Drug ID BADD_D00366
Description A nonsteroidal abortifacient agent that is effective in both the first and second trimesters of pregnancy.
Indications and Usage For aborting pregnancy between the 13th and 20th weeks of gestation as calculated from the first day of the last normal menstrual period and in the following conditions related to second trimester abortion: 1. Failure of expulsion of the fetus during the course of treatment by another method; 2. Premature rupture of membranes in intrauterine methods with loss of drug and insufficient or absent uterine activity; 3. Requirement of a repeat intrauterine instillation of drug for expulsion of the fetus; 4. Inadvertent or spontaneous rupture of membranes in the presence of a previable fetus and absence of adequate activity for expulsion. Also for the treatment of postpartum hemorrhage due to uterine atony which has not responded to conventional methods of management.
Marketing Status Prescription
ATC Code G02AD04
DrugBank ID DB00429
KEGG ID D00682
MeSH ID C062843
PubChem ID 5281074
TTD Drug ID D07PCI
NDC Product Code 68245-0016; 69784-240; 82231-103; 54893-0023; 43598-917; 70121-1680; 43598-698; 0009-0856; 43598-919
Synonyms carboprost tromethamine | carboprost trometamol | 15-methylprostaglandin F2alpha-tromethamine | Hemabate | Prostin M-15
Chemical Information
Molecular Formula C25H47NO8
CAS Registry Number 58551-69-2
SMILES CCCCCC(C)(C=CC1C(CC(C1CC=CCCCC(=O)O)O)O)O.C(C(CO)(CO)N)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Injection site pain08.02.03.010; 12.07.03.011--Not Available
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.008--
Muscle spasms15.05.03.004--
Myalgia15.05.02.001--
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Palpitations02.01.02.003--
Paraesthesia17.02.06.005--
Placental disorder18.05.02.001--Not Available
Presyncope24.06.02.010; 17.02.05.009; 02.01.02.007--
Pulmonary oedema22.01.03.003; 02.05.02.003--
Rash23.03.13.001--Not Available
Respiratory distress22.02.01.012--Not Available
Retching07.01.07.002--Not Available
Septic shock24.06.02.011; 11.01.11.004--Not Available
Sleep disorder19.02.04.001--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Syncope02.01.02.008; 24.06.02.012; 17.02.04.008--
Tachycardia02.03.02.007--Not Available
Thirst14.03.02.007; 08.01.09.021--Not Available
Throat tightness22.02.05.015; 19.01.02.005--Not Available
Thyrotoxic crisis05.02.02.004; 19.07.03.006; 14.11.01.016; 06.09.04.004--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Torticollis17.01.03.003; 15.05.04.003--Not Available
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
Urinary tract infection11.01.14.004; 20.08.02.001--
Uterine perforation21.07.01.010; 12.02.14.002--
Uterine rupture21.07.01.009; 18.02.02.001; 12.01.15.001--Not Available
Vertigo17.02.12.002; 04.04.01.003--
Vision blurred17.17.01.010; 06.02.06.007--
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