Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Carboplatin
Drug ID BADD_D00364
Description Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma.[L32253] Early clinical studies of carboplatin were performed in 1982.[A230523] Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.[L32248]
Indications and Usage Carboplatin is indicated in combination with an established combination of chemotherapeutic agents for the initial treatment of advanced ovarian carcinoma.[L32253] Carboplatin is also indicated for the palliative treatment of ovarian carcinoma, recurrent after prior chemotherapy.[L32253]
Marketing Status approved
ATC Code L01XA02
DrugBank ID DB00958
KEGG ID D01363
MeSH ID D016190
PubChem ID 426756
TTD Drug ID D0X7HM
NDC Product Code 0703-4239; 55150-386; 63323-172; 68083-191; 63592-0271; 61703-339; 0703-4244; 0703-4246; 72659-863; 50742-447; 69448-005; 61703-600; 55150-334; 61703-262; 61703-360; 71288-100; 49812-0010; 16729-295; 55150-333; 61703-150; 68083-193; 68554-0084; 68083-190; 68083-192; 53104-7570; 54875-0002; 50742-448; 55150-335; 0703-4248
UNII BG3F62OND5
Synonyms Carboplatin | cis-Diammine(cyclobutanedicarboxylato)platinum II | CBDCA | Paraplatin | Paraplatine | Platinwas | Ribocarbo | Carboplat | Neocarbo | Carbosin | Carbotec | Ercar | JM-8 | JM 8 | JM8 | Nealorin | NSC-241240 | NSC 241240 | NSC241240 | Blastocarb
Chemical Information
Molecular Formula C6H12N2O4Pt
CAS Registry Number 41575-94-4
SMILES C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Electrolyte imbalance14.05.01.0020.000672%Not Available
Embolic stroke17.08.01.032; 24.01.04.0100.000280%Not Available
Encephalopathy17.13.02.0010.000504%
Enteritis07.08.03.0020.000336%
Enterocolitis07.08.03.0030.000280%
Erythema23.03.06.0010.021434%Not Available
Exophthalmos05.02.02.002; 06.09.04.0010.000112%Not Available
Extravasation08.01.03.0080.000672%Not Available
Eye disorder06.08.03.001--Not Available
Eyelid oedema23.04.01.003; 10.01.05.001; 06.04.04.0040.000560%Not Available
Eyelid ptosis06.05.01.002; 17.17.02.0040.000112%Not Available
Face oedema23.04.01.004; 10.01.05.002; 08.01.07.0030.001477%
Facial pain08.01.08.0120.000112%
Facial paralysis17.04.03.0080.000224%Not Available
Faeces hard07.01.03.0030.000224%Not Available
Failure to thrive19.07.05.001; 18.04.01.003; 14.03.02.0080.000504%Not Available
Fatigue08.01.01.002--
Febrile neutropenia08.05.02.004; 01.02.03.0020.006660%
Feeling abnormal08.01.09.014--Not Available
Feeling hot08.01.09.0090.004992%Not Available
Fibrosis08.03.01.0010.000224%Not Available
Fistula15.03.02.0010.000112%Not Available
Flank pain20.02.03.006; 15.03.04.003; 08.01.08.0070.000470%
Flushing24.03.01.002; 23.06.05.003; 08.01.03.0250.011439%
Formication19.10.04.002; 17.02.06.0180.000392%Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal necrosis24.04.08.006; 07.15.01.0030.000168%
Gastrointestinal pain07.01.05.005--
Gastrointestinal perforation07.04.04.0010.000112%Not Available
Generalised oedema14.05.06.007; 08.01.07.0040.000280%
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ADReCS-Target
Drug Name ADR Term Target
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