Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Carboplatin
Drug ID BADD_D00364
Description Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma.[L32253] Early clinical studies of carboplatin were performed in 1982.[A230523] Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.[L32248]
Indications and Usage For the initial treatment of advanced ovarian carcinoma in established combination with other approved chemotherapeutic agents. One established combination regimen consists of PARAPLATIN and cyclophosphamide. It is also indicated for the palliative treatment of patients with ovarian carcinoma recurrent after prior chemotherapy, including patients who have been previously treated with cisplatin.
Marketing Status Prescription; Discontinued
ATC Code L01XA02
DrugBank ID DB00958
KEGG ID D01363
MeSH ID D016190
PubChem ID 426756
TTD Drug ID D0X7HM
NDC Product Code 0703-4239; 55150-335; 63592-0271; 68083-192; 49812-0010; 68554-0084; 53104-7570; 69448-005; 0703-4246; 54875-0002; 55150-386; 55150-334; 0703-4248; 55150-333; 63323-172; 72659-863; 68083-191; 71288-100; 16729-295; 0703-4244; 68083-193; 68083-190; 61703-339
Synonyms Carboplatin | cis-Diammine(cyclobutanedicarboxylato)platinum II | CBDCA | Paraplatin | Paraplatine | Platinwas | Ribocarbo | Carboplat | Neocarbo | Carbosin | Carbotec | Ercar | JM-8 | JM 8 | JM8 | Nealorin | NSC-241240 | NSC 241240 | NSC241240 | Blastocarb
Chemical Information
Molecular Formula C6H12N2O4Pt
CAS Registry Number 41575-94-4
SMILES C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood glucose decreased13.02.02.0010.000533%Not Available
Blood glucose increased13.02.02.0020.003197%Not Available
Blood magnesium decreased13.11.01.008--Not Available
Blood potassium decreased13.11.01.0100.003996%Not Available
Blood pressure decreased13.14.03.0020.011189%Not Available
Blood pressure increased13.14.03.0050.009324%Not Available
Blood pressure systolic increased13.14.03.0060.001598%Not Available
Blood sodium decreased13.11.01.0120.001332%Not Available
Blood urea increased13.13.01.006--Not Available
Body temperature decreased13.15.01.0100.000533%Not Available
Body temperature increased13.15.01.0010.001598%Not Available
Bradycardia02.03.02.002--Not Available
Bronchiolitis11.05.04.008; 22.03.02.0040.000533%Not Available
Bronchitis11.01.09.001; 22.07.01.001--
Bronchospasm22.03.01.004; 10.01.03.0120.009058%
Bronchostenosis22.03.01.0200.000533%
Bundle branch block left02.03.01.0070.000533%Not Available
Burning sensation17.02.06.001; 08.01.09.0290.002131%Not Available
Cachexia08.01.01.009; 16.32.03.011; 14.03.02.0010.000208%Not Available
Capillary leak syndrome08.01.07.012; 24.06.03.0010.000533%
Cardiac arrest02.03.04.001--
Cardiac failure02.05.01.001--
Cardiac failure acute02.05.01.0050.000139%Not Available
Cardiac failure congestive02.05.01.002--Not Available
Cardiac tamponade02.06.01.0010.000278%
Cardio-respiratory arrest22.02.06.007; 02.03.04.0020.001390%Not Available
Cardiogenic shock02.05.01.003; 24.06.02.0060.000347%Not Available
Cardiomyopathy02.04.01.0010.001598%Not Available
Cardiovascular disorder24.03.02.009; 02.01.01.0010.000625%Not Available
Carotid artery stenosis24.04.06.001; 17.08.02.0010.000799%Not Available
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