Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Carboplatin
Drug ID BADD_D00364
Description Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma.[L32253] Early clinical studies of carboplatin were performed in 1982.[A230523] Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.[L32248]
Indications and Usage Carboplatin is indicated in combination with an established combination of chemotherapeutic agents for the initial treatment of advanced ovarian carcinoma.[L32253] Carboplatin is also indicated for the palliative treatment of ovarian carcinoma, recurrent after prior chemotherapy.[L32253]
Marketing Status approved
ATC Code L01XA02
DrugBank ID DB00958
KEGG ID D01363
MeSH ID D016190
PubChem ID 426756
TTD Drug ID D0X7HM
NDC Product Code 0703-4239; 55150-386; 63323-172; 68083-191; 63592-0271; 61703-339; 0703-4244; 0703-4246; 72659-863; 50742-447; 69448-005; 61703-600; 55150-334; 61703-262; 61703-360; 71288-100; 49812-0010; 16729-295; 55150-333; 61703-150; 68083-193; 68554-0084; 68083-190; 68083-192; 53104-7570; 54875-0002; 50742-448; 55150-335; 0703-4248
UNII BG3F62OND5
Synonyms Carboplatin | cis-Diammine(cyclobutanedicarboxylato)platinum II | CBDCA | Paraplatin | Paraplatine | Platinwas | Ribocarbo | Carboplat | Neocarbo | Carbosin | Carbotec | Ercar | JM-8 | JM 8 | JM8 | Nealorin | NSC-241240 | NSC 241240 | NSC241240 | Blastocarb
Chemical Information
Molecular Formula C6H12N2O4Pt
CAS Registry Number 41575-94-4
SMILES C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Neutropenia01.02.03.0040.012055%Not Available
Nonspecific reaction08.01.03.0400.000381%Not Available
Odynophagia07.01.06.0360.000616%Not Available
Oedema14.05.06.010; 08.01.07.0060.001175%Not Available
Oedema mucosal08.01.06.0120.000280%Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Oesophageal pain07.01.05.0120.000280%
Oesophageal stenosis07.13.02.0010.000582%
Oesophageal ulcer07.04.05.0020.000168%
Oesophagitis07.08.05.0010.001063%
Onycholysis23.02.05.0040.000112%Not Available
Optic atrophy06.09.02.0010.000280%Not Available
Oral discomfort07.05.05.0010.000302%Not Available
Oral pain07.05.05.0340.000280%
Orthostatic hypotension24.06.03.004; 17.05.01.0200.000224%Not Available
Osteitis15.02.04.0150.000112%Not Available
Ototoxicity12.03.01.012; 04.03.01.0040.002406%Not Available
Ovarian cancer21.11.01.003; 16.12.04.0010.000336%Not Available
Pain08.01.08.004--
Pallor08.01.03.032; 24.03.04.001; 23.03.03.0310.001343%Not Available
Palmar erythema23.03.06.0100.001052%Not Available
Palmar-plantar erythrodysaesthesia syndrome23.03.05.009; 17.02.07.0090.001086%
Palpitations02.11.04.0120.001701%
Pancytopenia01.03.03.0030.005932%Not Available
Papilloedema24.03.07.001; 17.07.02.004; 06.09.02.0020.000504%
Paraesthesia23.03.03.094; 17.02.06.0050.004746%
Parathyroid disorder05.04.03.0010.000112%Not Available
Paresis17.01.04.0080.000168%Not Available
Pathological fracture16.32.03.007; 15.08.02.008; 12.04.02.0060.000112%Not Available
Pelvic venous thrombosis24.01.02.0080.000112%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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