Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Carbamazepine
Drug ID BADD_D00356
Description Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965.[A180301] Aside from the above uses, this drug is also given to control the symptoms of bipolar 1.[L1335] Interestingly, carbamazepine was the first anticonvulsant used to treat individuals with bipolar disorder.[A180319]
Indications and Usage For the treatment of epilepsy and pain associated with true trigeminal neuralgia.
Marketing Status Prescription; Discontinued
ATC Code N03AF01
DrugBank ID DB00564
KEGG ID D00252
MeSH ID D002220
PubChem ID 2554
TTD Drug ID D04MSM
NDC Product Code 60687-594; 51672-4123; 70518-3174; 67296-1637; 0781-5988; 68094-008; 0078-0509; 16571-682; 68084-561; 50090-5740; 68084-562; 0121-1894; 75834-221; 63629-8753; 70518-0181; 0904-7116; 68788-7825; 71335-0461; 51672-4047; 60505-2807; 60429-032; 50090-0384; 68071-4313; 0904-6172; 48087-0051; 70518-1769; 75834-220; 70518-2456; 68382-555; 42419-014; 29033-004; 30698-421; 16571-681; 16714-063; 0781-5987; 38779-0114; 50268-171; 70518-1433; 72189-157; 51927-2176; 54092-172; 13668-268; 51672-4124; 71930-072; 51552-0653; 70518-3176; 54092-173; 0615-3505; 0078-0508; 51672-4149; 35561-355; 65344-0028; 70518-1545; 0093-0090; 16714-065; 68382-557; 43063-328; 68788-7210; 0078-0512; 71930-073; 70518-3335; 68382-556; 71335-1730; 29033-019; 67386-621; 70518-3146; 70518-1436; 0781-8016; 51407-215; 49452-1705; 0832-6023; 43353-953; 70518-3266; 16714-064; 55154-1396; 76003-0251; 0078-0511; 0615-8125; 66993-409; 60505-2805; 60429-934; 51672-4150; 0093-0778; 17856-0407; 72664-218; 66993-407; 70518-2426; 51672-4151; 0832-6024; 63629-8255; 50090-2161; 70771-1469; 62512-0024; 70966-0020; 68094-007; 16571-680; 70518-2489; 60687-479; 70771-1470; 71205-025; 48087-0052; 35561-357; 51672-4005; 0121-1724; 13668-271; 60432-129; 71610-336; 60687-583; 63629-8743; 0121-0947; 70518-2841; 62991-1027; 35561-356; 0093-0109; 30698-419; 0904-6885; 70518-2653; 71930-074; 63552-060; 50090-4443; 63629-8721; 65372-1102; 71335-0691; 66993-408; 54092-171; 70771-1468; 63629-8720; 70518-2242; 0832-6022; 60505-0183; 60505-2806; 58118-0268; 0078-0510; 63629-8715; 51672-4041; 71335-0462; 50268-170; 29033-020; 0121-0862; 70518-0902; 50268-172; 0904-3854; 51672-4125; 30698-423
Synonyms Carbamazepine | Carbamazepine Acetate | Carbamazepine Dihydrate | Carbamazepine Hydrochloride | Carbamazepine L-Tartrate (4:1) | Carbamazepine Anhydrous | Carbamazepine Sulfate (2:1) | Carbazepin | Epitol | Finlepsin | Neurotol | Tegretol | Amizepine | Carbamazepine Phosphate
Chemical Information
Molecular Formula C15H12N2O
CAS Registry Number 298-46-4
SMILES C1=CC=C2C(=C1)C=CC3=CC=CC=C3N2C(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Drug dependenceBifunctional epoxide hydrolase 2P34913T357348877250; 3146222; 8968658; 10380060
HepatotoxicityCytochrome P450 3A4P08684T378481575766; 8723729; 8347124
HypersensitivityEpoxide hydrolase 1P07099Not Available7503783; 7503784
Nephropathy toxicGlutathione hydrolase 1 proenzymeP19440Not Available8125216; 8457719; 1508841; 7785052; 15856183; 8494733; 8720036; 15223355
PorphyriaDelta-aminolevulinic acid dehydrataseP13716T205143181278; 6428897; 71507; 4067519; 3130256; 913061; 7120315; 463487; 4096716; 2500271; 6780356; 3813879; 2429498; 1165472; 6896622; 6800821
PorphyriaDelta-aminolevulinic acid dehydrataseQ5TJH2Not Available3181278; 6428897; 71507; 4067519; 3130256; 913061; 7120315; 463487; 4096716; 2500271; 6780356; 3813879; 2429498; 1165472; 6896622; 6800821
Renal impairmentBeta-2-microglobulinP61769T580803280573; 2679841; 6392147
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dysuria20.02.02.0020.002947%
Ear disorder04.03.01.001--Not Available
Ear malformation04.06.02.001; 03.13.02.0010.001263%Not Available
Ear pain04.03.01.0030.002105%
Ear swelling04.03.01.0140.000842%Not Available
Eating disorder19.09.01.008; 14.03.01.0080.003368%Not Available
Ectopic pregnancy18.02.02.0020.001263%Not Available
Eczema23.03.04.0060.003789%
Electrocardiogram abnormal13.14.05.0010.001263%Not Available
Electrocardiogram QRS complex13.14.05.034--Not Available
Electrocardiogram QRS complex prolonged13.14.05.0030.002947%Not Available
Electrocardiogram QT prolonged13.14.05.0040.008840%
Electroencephalogram abnormal13.07.03.0010.005893%Not Available
Electrolyte imbalance14.05.01.0020.001208%Not Available
Embolism venous24.01.01.003--Not Available
Emotional disorder19.04.02.0050.001684%Not Available
Emphysema22.01.02.0020.000220%Not Available
Encephalitis17.06.05.001; 11.01.03.0080.001263%
Encephalopathy17.13.02.0010.005893%
Endocrine disorder05.09.01.0010.000842%Not Available
Eosinophil count increased13.01.06.0040.005052%Not Available
Eosinophilia01.02.04.0010.017259%
Eosinophilic pneumonia22.01.01.004; 01.02.04.0030.001263%Not Available
Epidermolysis bullosa23.03.01.010; 03.05.01.0010.001263%Not Available
Epilepsy17.12.03.0020.057671%Not Available
Epistaxis24.07.01.005; 22.04.03.001--
Epstein-Barr virus infection11.05.10.0040.001263%
Erythema23.03.06.0010.034940%Not Available
Erythema multiforme23.03.01.003; 10.01.03.0150.013471%
Erythema nodosum23.07.02.001; 10.02.01.020--Not Available
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