Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Carbamazepine
Drug ID BADD_D00356
Description Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965.[A180301] Aside from the above uses, this drug is also given to control the symptoms of bipolar 1.[L1335] Interestingly, carbamazepine was the first anticonvulsant used to treat individuals with bipolar disorder.[A180319]
Indications and Usage Carbamazepine is indicated for the treatment of epilepsy and pain associated with true trigeminal neuralgia.[L1335] In particular, carbamazepine has shown efficacy in treating mixed seizures, partial seizures with complex symptoms, and generalized tonic-clonic seizures.[A180301,L1335] Carbamazepine is also indicated for the treatment of manic episodes and mixed manic-depressive episodes caused by bipolar I disorder.[L1335] Some off-label, unapproved uses of carbamazepine include the treatment of alcohol withdrawal syndrome and restless leg syndrome.[A180415,A180421]
Marketing Status approved; investigational
ATC Code N03AF01
DrugBank ID DB00564
KEGG ID D00252
MeSH ID D002220
PubChem ID 2554
TTD Drug ID D04MSM
NDC Product Code 62512-0024; 30698-421; 50268-172; 60687-583; 63629-9292; 66993-409; 70518-3266; 70771-1470; 0615-8125; 0781-5987; 0904-6885; 49452-1705; 63552-060; 0078-0510; 0078-0511; 16571-681; 16714-064; 0093-0778; 17856-0029; 29033-019; 30698-419; 35561-355; 50090-0384; 51672-4047; 51672-4151; 54092-173; 60429-934; 60687-594; 63629-8721; 70518-0181; 70771-1469; 70954-240; 71205-025; 75834-220; 12658-0525; 12658-0526; 0904-7116; 42419-014; 35561-357; 51672-4149; 54092-171; 59746-789; 60505-2805; 63629-8743; 66993-407; 67386-621; 68788-7210; 70518-1433; 59746-790; 63629-8753; 68084-562; 68382-557; 70518-3176; 0781-5988; 16714-063; 27241-233; 29033-004; 29300-382; 35561-356; 51407-215; 60505-2807; 70518-1545; 71930-073; 72162-2021; 0781-8016; 0832-6022; 12658-0561; 12658-0565; 48087-0051; 70966-0020; 76003-0251; 13668-268; 0093-0109; 27241-232; 43063-328; 50268-170; 54092-172; 60505-2806; 68788-7825; 70518-1436; 70518-2242; 70518-3335; 71335-0461; 71335-0691; 71930-072; 75834-221; 0904-3854; 51927-2176; 13668-271; 51672-4125; 63629-8715; 68084-444; 68382-555; 70518-1769; 70518-2456; 70518-3699; 70518-3773; 0832-6023; 12658-0452; 51552-0653; 62991-1027; 65344-0028; 65344-0040; 0078-0512; 27241-231; 0121-0947; 43353-953; 59746-791; 70518-2426; 70518-3146; 71930-074; 72189-157; 0904-6172; 12658-0406; 12658-0541; 0078-0509; 0093-0090; 29033-020; 51672-4005; 51672-4123; 55154-1396; 60505-0183; 60687-479; 63629-8720; 68094-007; 68382-556; 70518-2841; 70518-3591; 70518-3694; 71335-1730; 12658-0486; 38779-0114; 48087-0052; 0078-0508; 16714-065; 30698-423; 50268-171; 51672-4150; 58118-0268; 66993-408; 68071-2701; 70518-2489; 70518-3174; 70771-1468; 0615-3505; 72664-218; 0832-6024; 65372-1102; 16571-680; 16571-682; 0121-1894; 50090-5740; 51672-4041; 51672-4124; 60429-032
UNII 33CM23913M
Synonyms Carbamazepine | Carbamazepine Acetate | Carbamazepine Dihydrate | Carbamazepine Hydrochloride | Carbamazepine L-Tartrate (4:1) | Carbamazepine Anhydrous | Carbamazepine Sulfate (2:1) | Carbazepin | Epitol | Finlepsin | Neurotol | Tegretol | Amizepine | Carbamazepine Phosphate
Chemical Information
Molecular Formula C15H12N2O
CAS Registry Number 298-46-4
SMILES C1=CC=C2C(=C1)C=CC3=CC=CC=C3N2C(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Suicide attempt19.12.01.0040.006602%
Superior sagittal sinus thrombosis17.08.03.001; 24.01.04.0040.000186%Not Available
Supraventricular tachycardia02.03.03.0120.000409%
Sweat gland tumour16.26.01.009; 23.10.01.0090.000279%Not Available
Swelling08.01.03.0150.001860%Not Available
Swelling face08.01.03.100; 23.04.01.018; 10.01.05.0180.004445%Not Available
Swollen tongue23.04.01.014; 10.01.05.015; 07.14.02.0030.000874%Not Available
Syncope02.11.04.015; 24.06.02.012; 17.02.04.0080.002883%
Systemic lupus erythematosus10.04.03.004; 23.03.02.006; 15.06.02.0030.000651%Not Available
Systemic lupus erythematosus rash23.03.13.007; 15.06.02.005; 10.04.03.005--Not Available
Tachycardia02.03.02.0070.003385%Not Available
Tachypnoea22.02.01.0140.000465%Not Available
Tension19.06.02.0050.000279%Not Available
Testicular atrophy21.13.01.001; 05.05.02.004--Not Available
Tetany15.05.03.013; 14.04.01.005; 05.04.02.0030.000279%Not Available
Therapeutic response decreased08.06.01.016--Not Available
Thinking abnormal19.10.03.001; 17.02.05.0230.000372%Not Available
Thrombocytopenia01.08.01.0020.006416%Not Available
Thrombocytopenic purpura23.06.01.007; 01.08.01.0030.000651%Not Available
Thrombocytosis01.08.02.0010.000651%Not Available
Thrombophlebitis24.01.02.001--Not Available
Thyroid function test abnormal13.10.06.001--Not Available
Thyroiditis05.02.04.0010.000186%Not Available
Tic17.02.05.024; 19.11.04.0010.000279%Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Tongue discolouration07.14.02.0060.000465%Not Available
Tongue oedema07.14.02.007; 23.04.01.009; 10.01.05.0080.000279%Not Available
Tongue ulceration07.14.01.0030.000186%Not Available
Tonic convulsion17.12.03.0110.000372%Not Available
Tonsillar hypertrophy22.04.05.0060.000186%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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