| Pharmaceutical Information |
| Drug Name |
Caffeine |
| Drug ID |
BADD_D00332 |
| Description |
Caffeine is a drug of the methylxanthine class used for a variety of purposes, including certain respiratory conditions of the premature newborn, pain relief, and to combat drowsiness. Caffeine is similar in chemical structure to [Theophylline] and [Theobromine].[A187691,L9851] It can be sourced from coffee beans, but also occurs naturally in various teas and cacao beans, which are different than coffee beans.[T716] Caffeine is also used in a variety of cosmetic products and can be administered topically, orally, by inhalation, or by injection.[T716]
The caffeine citrate injection, used for apnea of the premature newborn, was initially approved by the FDA in 1999.[L9863] According to an article from 2017, more than 15 million babies are born prematurely worldwide. This correlates to about 1 in 10 births. Premature birth can lead to apnea and bronchopulmonary dysplasia, a condition that interferes with lung development and may eventually cause asthma or early onset emphysema in those born prematurely.[A187694] Caffeine is beneficial in preventing and treating apnea and bronchopulmonary dysplasia in newborns, improving the quality of life of premature infants.[T716] |
| Indications and Usage |
For management of fatigue, orthostatic hypotension, and for the short term treatment of apnea of prematurity in infants. |
| Marketing Status |
Not Available |
| ATC Code |
D11AX26; N06BC01 |
| DrugBank ID |
DB00201
|
| KEGG ID |
D00528
|
| MeSH ID |
D002110
|
| PubChem ID |
2519
|
| TTD Drug ID |
D0B3HD
|
| NDC Product Code |
41250-320; 21130-944; 65724-4012; 66715-5930; 55301-226; 63083-1508; 70677-0021; 76162-002; 49035-226; 58624-0306; 65724-4013; 38779-0419; 0363-5009; 56062-030; 53943-320; 41163-226; 11822-0691; 72036-020; 63941-020; 65724-4000; 51552-0200; 69842-509; 68016-680; 10267-5010; 66715-5830; 62959-955; 41520-708; 33992-2261; 0113-0409; 69842-500; 66715-5530; 50804-262; 46122-457; 58624-0308; 0363-0226; 58624-0310; 58624-0302; 66715-9799; 58624-0312; 36800-844; 0363-3440; 30142-726; 68210-4030; 11822-2260; 69168-076; 63868-114; 21130-226; 62959-954; 52389-155; 58624-0534; 49452-1320; 63940-229; 67091-117; 58624-0316; 72476-102; 57243-226; 37808-409; 52389-656; 62011-0340; 55319-226; 68998-076; 58624-0314; 70000-0154; 66715-5730; 58624-0304; 59779-345; 15579-201; 70000-0409; 55910-226; 46017-012; 52389-406; 65724-4004; 67751-160; 49483-343; 65724-4008; 56062-409; 41163-434 |
| Synonyms |
Caffeine | 1,3,7-Trimethylxanthine | Vivarin | Caffedrine | Coffeinum N | Percutaféine | Dexitac | Durvitan | No Doz | Percoffedrinol N | Quick-Pep | Quick Pep | QuickPep | Coffeinum Purrum |
|
| Chemical Information |
| Molecular Formula |
C8H10N4O2 |
| CAS Registry Number |
58-08-2 |
| SMILES |
CN1C=NC2=C1C(=O)N(C(=O)N2C)C |
| Chemical Structure |
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| ADR Related Proteins Induced by Drug |
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| ADRs Induced by Drug |
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