Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cabazitaxel
Drug ID BADD_D00328
Description Cabazitaxel is an anti-neoplastic used with the steroid medicine prednisone. Cabazitaxel is used to treat people with prostate cancer that has progressed despite treatment with docetaxel. Cabazitaxel is prepared by semi-synthesis with a precursor extracted from yew needles (10-deacetylbaccatin III). It was approved by the U.S. Food and Drug Administration (FDA) on June 17, 2010.
Indications and Usage For treatment of patients with hormone-refractory metastatic prostate cancer previously treated with a docetaxel-containing treatment regimen.
Marketing Status Prescription
ATC Code L01CD04
DrugBank ID DB06772
KEGG ID D09755
MeSH ID C552428
PubChem ID 9854073
TTD Drug ID D02HSB
NDC Product Code 54893-0016; 55111-962; 68554-0080; 0024-5824; 47848-044; 61200-101
Synonyms cabazitaxel | kabazitaxel | Jevtana
Chemical Information
Molecular Formula C45H57NO14
CAS Registry Number 183133-96-2
SMILES CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O) O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)OC)C)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypoaesthesia17.02.06.023--Not Available
Hypokalaemia14.05.03.002--
Hypotension24.06.03.002--
Ileus07.13.01.001--
Immune system disorder10.02.01.001--Not Available
Infection11.01.08.002--Not Available
Influenza22.07.02.001; 11.05.03.001--Not Available
Intestinal obstruction07.13.01.002--Not Available
Laboratory test abnormal13.18.01.001--Not Available
Lacrimation increased06.08.02.004--
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.008--
Leukopenia01.02.02.001--Not Available
Malaise08.01.01.003--
Menopausal symptoms21.02.02.002--Not Available
Mucosal inflammation08.01.06.002--Not Available
Muscle spasms15.05.03.004--
Myalgia15.05.02.001--
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Neutropenia01.02.03.004--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Oedema peripheral02.05.04.007; 14.05.06.011; 08.01.07.007--
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Paraesthesia17.02.06.005--
Pelvic pain21.10.01.001; 07.01.06.012; 20.02.03.007--
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