Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Butorphanol
Drug ID BADD_D00324
Description A synthetic morphinan analgesic with narcotic antagonist action. It is used in the management of severe pain.
Indications and Usage For the relief of moderate to severe pain.
Marketing Status Prescription; Discontinued
ATC Code N02AF01
DrugBank ID DB00611
KEGG ID D03197
MeSH ID D002077
PubChem ID 5361092
TTD Drug ID D0X9RG
NDC Product Code Not Available
Synonyms Butorphanol | 17-(Cyclobutylmethyl)morphinan-3,14-diol | BC-2627 | BC 2627 | BC2627 | Beforal | Butorphanol Tartrate | Moradol | Stadol | Stadol NS | Torbugesic | Apo-Butorphanol | Dolorex
Chemical Information
Molecular Formula C21H29NO2
CAS Registry Number 42408-82-2
SMILES C1CCC2(C3CC4=C(C2(C1)CCN3CC5CCC5)C=C(C=C4)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypotension24.06.03.002--
Hypotonia17.05.02.002; 15.05.04.008--Not Available
Hypoventilation22.02.01.007--Not Available
Hypoxia22.02.02.003--
Increased appetite14.03.01.003; 08.01.09.027--Not Available
Injury12.01.08.004--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.008--
Libido increased21.03.02.007; 19.08.03.002--
Loss of consciousness17.02.04.004--Not Available
Mental disability26.01.01.001--Not Available
Muscle spasms15.05.03.004--
Nasal congestion22.04.04.001--
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Osteoarthritis15.01.04.001--Not Available
Pain in extremity15.03.04.010--
Pallor24.03.04.001; 23.03.03.031; 08.01.03.032--Not Available
Palpitations02.01.02.003--
Paraesthesia17.02.06.005--
Paresis17.01.04.008--Not Available
Petechiae23.06.01.003; 01.01.03.002; 24.07.06.004--Not Available
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Photophobia17.17.02.006; 06.01.01.004--
Pruritus23.03.12.001--
Psychomotor retardation19.15.02.002--Not Available
Rash23.03.13.001--Not Available
Respiratory failure14.01.04.003; 22.02.06.002--
Rhinitis22.07.03.006; 11.01.13.004--
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