Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bumetanide
Drug ID BADD_D00307
Description Bumetanide is a sulfamyl diuretic.
Indications and Usage For the treatment of edema associated with congestive heart failure, hepatic and renal disease including the nephrotic syndrome.
Marketing Status Prescription; Discontinued
ATC Code C03CA02
DrugBank ID DB00887
KEGG ID D00247
MeSH ID D002034
PubChem ID 2471
TTD Drug ID D0R7HO
NDC Product Code 0185-0129; 17337-0011; 51662-1449; 50268-130; 30698-631; 50090-5123; 68071-4330; 60687-384; 50090-5663; 30698-630; 14539-701; 0641-6008; 69238-1489; 42799-120; 68071-3128; 68382-526; 50090-5064; 50268-131; 16714-832; 14539-700; 68382-527; 70518-2678; 14501-0036; 0904-7016; 60468-001; 72572-041; 0832-0542; 70860-405; 70771-1026; 0185-0130; 50090-5666; 43353-288; 0641-6007; 68382-525; 50268-132; 0409-1412; 14539-702; 50090-5124; 0832-0541; 42799-119; 0832-0540; 50090-5065; 57755-0004; 63629-7440; 55154-4733; 0615-8394; 70771-1024; 63190-0430; 16714-831; 0641-6161; 71335-1692; 60687-535; 71335-1201; 50090-5068; 63190-0370; 0615-8361; 0615-8362; 16714-833; 0615-8393; 63629-4968; 60468-003; 42799-121; 0185-0128; 43353-292; 72572-040; 70860-406; 69238-1491; 50090-5664; 55154-4345; 70771-1025; 71335-0016; 17337-0055; 68071-4350; 60468-002; 30698-632; 55154-3572; 70518-3191; 0641-6162; 69238-1490
Synonyms Bumetanide | Bumethanide | Bumex | PF-1593 | PF 1593 | PF1593 | Drenural | Fordiuran | Miccil | Bumedyl | Burinex
Chemical Information
Molecular Formula C17H20N2O5S
CAS Registry Number 28395-03-1
SMILES CCCCNC1=C(C(=CC(=C1)C(=O)O)S(=O)(=O)N)OC2=CC=CC=C2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Muscle spasms15.05.03.0040.009653%
Muscular weakness15.05.06.001; 17.05.03.0050.001287%
Musculoskeletal pain15.03.04.0070.001287%
Myalgia15.05.02.0010.022523%
Nausea07.01.07.001--
Nipple pain21.05.05.009--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.0070.001931%
Orthostatic hypotension24.06.03.004; 17.05.01.0200.001287%Not Available
Pain08.01.08.0040.001931%
Pancreatitis07.18.01.001--
Polyuria20.02.03.0020.003218%Not Available
Premature ejaculation21.03.01.008; 19.08.01.002--Not Available
Protein total abnormal13.09.01.008--Not Available
Prothrombin time13.01.02.038--Not Available
Pruritus23.03.12.0010.001931%
Rash23.03.13.0010.002574%Not Available
Renal failure20.01.03.005--Not Available
Sepsis11.01.11.0030.000336%
Stevens-Johnson syndrome23.03.01.007; 12.03.01.014; 11.07.01.005; 10.01.03.020--
Syncope02.01.02.008; 24.06.02.012; 17.02.04.0080.001287%
Thrombocytopenia01.08.01.002--Not Available
Toxic epidermal necrolysis10.01.01.006; 23.03.01.008; 12.03.01.015; 11.07.01.006--
Urticaria23.04.02.001; 10.01.06.0010.001931%
Vertigo17.02.12.002; 04.04.01.003--
Vomiting07.01.07.003--
Weight decreased13.15.01.0050.002574%
Weight increased13.15.01.0060.001287%
White blood cell count13.01.06.027--Not Available
Hypoacusis04.02.01.006--
Peripheral swelling08.01.03.053; 02.05.04.0150.001287%Not Available
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