Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bimatoprost
Drug ID BADD_D00274
Description Bimatoprost, also known as Latisse or Lumigan, belongs to a group of drugs called prostamides, which are synthetic structural analogs of prostaglandin. Bimatoprost, marketed by Allergan, is administered in both the ophthalmic solution and implant form. It has the ability to reduce ocular hypotension, proving effective in conditions such as ocular hypertension and glaucoma.[L6877,L6892,L6898,L12069] Bimatoprost is also used to treat eyelash hypotrichosis, or sparse eyelash growth.[L6910] It was initially approved by the FDA in 2001 for ocular hypertension and later approved for hypothrichosis in 2008, as eyelash growth became a desirable adverse effect for patients using this drug.[L4894]
Indications and Usage For the reduction of elevated intraocular pressure in patients with open angle glaucoma or ocular hypertension who are intolerant of other intraocular pressure lowering medications or insufficiently responsive (failed to achieve target IOP determined after multiple measurements over time) to another intraocular pressure lowering medication.
Marketing Status Prescription; Discontinued
ATC Code S01EE03
DrugBank ID DB00905
KEGG ID D02724
MeSH ID D000069580
PubChem ID 5311027
TTD Drug ID D0Q2XF
NDC Product Code 72266-139; 0023-3616; 82187-1001; 68083-439; 50383-912; 71052-276; 40016-005; 24002-0021; 70069-401; 0781-6206; 65129-1206; 42571-128; 62332-511; 76397-016; 73309-002; 46144-328; 54893-0009; 57741-3000; 55679-113; 82231-102; 73309-022; 0023-3205; 60505-0583; 68180-429; 50383-908; 63190-0290; 70069-402; 68245-0004; 65035-130; 72266-140; 70069-403; 62332-507; 54245-7036; 0023-9652; 68083-295; 65727-025; 72266-241; 12079-1067; 68083-296; 38779-3066; 61556-070
Synonyms Bimatoprost | Latisse | Lumigan | AGN 192024 | 192024, AGN
Chemical Information
Molecular Formula C25H37NO4
CAS Registry Number 155206-00-1
SMILES CCNC(=O)CCCC=CCC1C(CC(C1C=CC(CCC2=CC=CC=C2)O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cardiac failure02.05.01.001--
Cataract06.06.01.0010.003013%
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chalazion06.04.04.002--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chronic obstructive pulmonary disease22.03.01.0070.000674%Not Available
Conjunctival haemorrhage24.07.05.001; 06.07.01.001--Not Available
Conjunctival oedema06.04.01.001--Not Available
Conjunctivitis11.01.06.012; 06.04.01.0020.004304%
Conjunctivitis allergic10.01.04.002; 06.04.01.0030.001722%Not Available
Corneal deposits06.06.03.002--Not Available
Corneal epithelium defect06.06.03.0120.000861%Not Available
Corneal erosion06.06.03.0030.001722%Not Available
Corneal infiltrates06.08.01.0020.000861%Not Available
Corneal oedema06.04.02.0010.001291%Not Available
Cough22.02.03.001--
Cystitis11.01.14.001; 20.03.02.002--
Death08.04.01.001--
Depression19.15.01.001--
Dermatitis23.03.04.0020.000861%Not Available
Diarrhoea07.02.01.001--
Diplopia17.17.01.005; 06.02.06.0020.002583%Not Available
Discomfort08.01.08.0030.000861%Not Available
Disorientation19.13.01.002; 17.02.05.015--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Drug hypersensitivity10.01.01.001--Not Available
Dry eye06.08.02.0010.018508%
Dry mouth07.06.01.002--
Dry skin23.03.03.0010.001722%
Dyspepsia07.01.02.001--
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