Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Betahistine
Drug ID BADD_D00258
Description Ménière's disease is a progressive disease of the inner ear characterized by vertigo, tinnitus, and hearing loss. It has a significant impact on both the physical and social functioning of affected individuals.[A220318,L16408] Betahistine is a histamine-like antivertigo drug used for treating symptoms associated with Ménière's disease. It is thought to reduce symptoms through its actions on histamine receptors.[A220333,L16403] Betahistine was first approved by the FDA in the 1970s but withdrawn within approximately 5 years due to a lack of evidence supporting its efficacy. It is currently marketed in Canada by various companies, including Teva Pharmaceuticals.
Indications and Usage For the reduction of episodes of vertigo association with Ménière's disease.
Marketing Status Not Available
ATC Code N07CA01
DrugBank ID DB06698
KEGG ID D07522
MeSH ID D001621
PubChem ID 2366
TTD Drug ID D0XW9U
NDC Product Code Not Available
Synonyms Betahistine | Aequamen | Betahistin-Ratiopharm | Betahistin Ratiopharm | Betahistine Dihydrobromide | Dihydrobromide, Betahistine | Betahistine Hydrochloride | Hydrochloride, Betahistine | Betahistine Dihydrochloride | Dihydrochloride, Betahistine | Betahistine Mesylate | Mesylate, Betahistine | Betahistine Methanesulphonate | Methanesulphonate, Betahistine | Betahistine Methanesulfonate | Methanesulfonate, Betahistine | Betavert | By-Vertin | By Vertin | Extovyl | Fidium | Lectil | Melopat | Mersilon | PT-9 | PT 9 | PT9 | Ribrain | Serc | Betaserc | Vasomotal | Betahistine Biphar | Vertigon | Betahistin AL | Betahistin Stada
Chemical Information
Molecular Formula C8H12N2
CAS Registry Number 5638-76-6
SMILES CNCCC1=CC=CC=N1
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain upper07.01.05.003--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Confusional state19.13.01.001; 17.02.03.005--
Dermatitis23.03.04.002--Not Available
Dermatitis allergic10.01.03.014; 23.03.04.003--Not Available
Dermatitis atopic23.03.04.016; 10.01.04.004--Not Available
Diarrhoea07.02.01.001--
Discomfort08.01.08.003--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dyspepsia07.01.02.001--
Dyspnoea22.02.01.004; 02.01.03.002--
Erythema multiforme23.03.01.003; 10.01.03.015--
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Flatulence07.01.04.002--
Gastrointestinal disorder07.11.01.001--Not Available
Hallucination19.10.02.002--
Headache17.14.01.001--
Hypersensitivity10.01.03.003--
Immune system disorder10.02.01.001--Not Available
Malaise08.01.01.003--
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Pruritus23.03.12.001--
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