Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Benzalkonium chloride
Drug ID BADD_D00235
Description Benzalkonium is a quaternary ammonium compound used as a biocide, a cationic surfactant, and as a phase transfer agent [FDA Label]. Benzalkonium is more commonly contained in consumer products in its salt form, benzalkonium chloride [FDA Label]. This salt is used in a great variety of international pharmaceutical products such as eye, ear, and nasal drops or sprays as an excipient ingredient serving as an antimicrobial preservative [FDA Label]. When used as an ingredient in antiseptic and disinfectant products however, it is an active antimicrobial agent [L1806].
Indications and Usage Conversely, when implemented as an excipient ingredient in a variety of multidose aqueous nose, eye, or ear products, benzalkonium chloride is being used as the antimicrobial preservative of choice to facilitate effective bactericidal and fungicidal actions to help minimize the growth of unwanted organisms in the multidose containers [FDA Label].
Marketing Status Not Available
ATC Code D08AJ01; D09AA11; R02AA16
DrugBank ID DB11105
KEGG ID D00857
MeSH ID D001548
PubChem ID Not Available
TTD Drug ID Not Available
NDC Product Code 73857-008; 71897-118; 76896-002; 76176-064; 42926-004; 47682-122; 69842-326; 71584-0111; 11822-1020; 78641-207; 79293-003; 52000-047; 55316-196; 60867-150; 72146-019; 71020-003; 59050-260; 50157-517; 79937-011; 20890-0040; 90026-030; 80581-087; 53329-158; 76176-042; 43269-101; 44577-711; 18949-710; 73857-006; 80755-010; 50563-440; 54860-118; 63148-350; 73733-100; 73857-003; 0498-9001; 90014-002; 82062-201; 76744-250; 73746-014; 76176-098; 11084-301; 78691-009; 50563-421; 76176-158; 42377-010; 71212-102; 20276-434; 30142-575; 76176-151; 43333-514; 79310-304; 71734-331; 47593-645; 56136-313; 72288-575; 70412-500; 11084-306; 76922-936; 79310-302; 71020-020; 47593-595; 63148-108; 59050-331; 57337-049; 43269-959; 66949-387; 10819-3740; 63148-273; 35000-733; 56136-375; 74955-049; 76176-156; 71095-011; 59050-263; 68062-2241; 63002-005; 69139-202; 67502-118; 61333-208; 72146-024; 20276-144; 70888-001; 47593-584; 56136-516; 11822-1243; 20890-0050; 43269-119; 86815-003; 47593-572; 66949-128; 71884-011; 60867-200; 52410-8090; 43333-490; 56062-403; 47593-581; 28691-0011; 71853-001; 73027-218; 78874-500; 71734-303; 76849-101; 57337-048; 90020-000; 60933-200; 74934-046; 74146-243; 42281-101; 71095-007; 82289-1836; 20276-141; 11822-1240; 74955-054; 20276-148; 79705-003; 80894-010; 56136-202; 56136-084; 75687-111; 79021-003; 43269-124; 47593-543; 63148-512; 71120-118; 75356-0007; 81529-003; 57702-501; 20276-140; 69560-345; 76176-157; 20890-0110; 47593-512; 79293-001; 57337-045; 21749-112; 43333-526; 35000-415; 35000-083; 71489-005; 77071-000; 77784-003; 43333-517; 73015-001; 73741-107; 65133-190; 73126-008; 37808-952; 73795-001; 80499-006; 60867-302; 71095-014; 43269-986; 43269-996; 69540-0030; 77142-006; 50241-317; 66975-104; 54860-109; 70415-405; 77071-006; 79096-002; 79893-702; 49035-446; 73027-219; 50563-457; 53125-700; 80499-004; 68062-2242; 49035-036; 76922-938; 35000-082; 73126-006; 73249-105; 79021-005; 79956-003; 59110-400; 73760-006; 73030-020; 56136-390; 71584-0103; 70299-001; 82055-013; 73126-013; 43333-524; 65910-014; 77071-001; 77816-505; 74131-001; 42926-160; 63148-101; 74934-048; 76635-006; 75687-112; 39892-0305; 20276-149; 20276-138; 80755-000; 78804-215; 81608-001; 80499-010; 49681-015; 70415-503; 78691-003; 73787-111; 73485-002; 47593-511; 69139-400; 63148-514; 73126-029; 70956-100; 73215-101; 73760-001; 21749-368; 49687-0011; 80894-011; 73360-003; 52553-005; 66294-431; 73787-134; 57243-641; 73746-028; 80969-501; 72487-003; 80948-014; 72133-049; 73787-113; 52000-041; 42926-008; 35000-675; 78564-002; 69884-706; 0420-1202; 63148-109; 51316-001; 74416-006; 42926-165; 78564-000; 50157-050; 77617-009; 11344-017; 69446-210; 75266-058; 73787-107; 25119-0242; 43333-512; 54860-112; 80765-002; 79244-001; 74646-1050; 78823-028; 78940-001; 78823-006; 43269-946; 63148-724; 63621-387; 73857-007; 43333-508; 47593-568; 73737-436; 34645-0009; 81575-002; 73408-030; 47682-056; 73746-003; 43333-545; 81560-001; 74934-070; 75127-001; 90020-001; 42961-224; 80499-011; 49354-065; 63148-198; 56136-493; 11429-1001; 41250-976; 51606-002; 11822-2953; 63146-109; 76378-023; 23957-000; 79310-303; 78974-0003; 63354-903; 74154-006; 43269-988; 71370-700; 79531-003; 50563-408; 55910-628; 33992-1450; 51870-004; 76095-020; 69583-029; 78040-100; 73126-010; 71095-009; 71509-002; 47682-245; 59110-401
Synonyms Benzalkonium Compounds | Compounds, Benzalkonium | Osvan | Zephiran | Drapolene | BTC-2125 | BTC 2125 | BTC2125 | Germex | Asepsol | Benzalkonium | Benzalkonium Chloride | Chloride, Benzalkonium | Alkyldimethylbenzylammonium Chloride | Chloride, Alkyldimethylbenzylammonium
Chemical Information
Molecular Formula Not Available
CAS Registry Number
SMILES Not Available
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Purpura01.01.04.003; 24.07.06.005; 23.06.01.004--
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Restlessness19.11.02.002; 17.02.05.021--
Shock24.06.02.002--Not Available
Skin irritation23.03.04.009--Not Available
Stevens-Johnson syndrome23.03.01.007; 12.03.01.014; 11.07.01.005; 10.01.03.020--
Stomatitis07.05.06.005--
Thrombocytopenia01.08.01.002--Not Available
Thrombophlebitis24.01.02.001--Not Available
Tinnitus04.04.01.002; 17.04.07.004--
Toxic epidermal necrolysis23.03.01.008; 11.07.01.006; 12.03.01.015; 10.01.01.006--
Urticaria23.04.02.001; 10.01.06.001--
Vasculitis necrotising24.05.02.002; 10.02.02.008--Not Available
Vertigo17.02.12.002; 04.04.01.003--
Vision blurred17.17.01.010; 06.02.06.007--
Vomiting07.01.07.003--
Xanthopsia06.02.05.002--Not Available
Tubulointerstitial nephritis20.05.02.002--Not Available
Acute generalised exanthematous pustulosis12.03.01.005; 23.03.10.002--Not Available
Bladder spasm20.02.02.013--
Epigastric discomfort07.01.02.004--Not Available
Hepatic enzyme increased13.03.01.019--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Drug reaction with eosinophilia and systemic symptoms23.03.05.005; 10.01.01.021--Not Available
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