Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Benazepril hydrochloride
Drug ID BADD_D00228
Description Benazepril, brand name Lotensin, is a medication used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure[A838,A837]. Upon cleavage of its ester group by the liver, benazepril is converted into its active form benazeprilat, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor[A836].
Indications and Usage For the treatment of hypertension. It may be used alone or in combination with thiazide diuretics.
Marketing Status Prescription; Discontinued
ATC Code C09AA07
DrugBank ID DB00542
KEGG ID D00620
MeSH ID C044946
PubChem ID 5362123
TTD Drug ID D0U3EC
NDC Product Code 71335-0854; 61919-756; 70934-228; 68071-5028; 68071-5087; 70518-3074; 61919-280; 50268-112; 71052-173; 68788-9327; 50268-109; 65862-118; 63187-906; 51927-0036; 43547-335; 71335-1365; 50090-5750; 68788-7845; 55154-4343; 68071-1769; 60760-352; 68071-4198; 50268-110; 51927-0105; 50268-111; 70518-3171; 68071-5088; 65162-751; 15308-0900; 65862-117; 42291-163; 50090-3359; 71335-0011; 68071-1026; 55700-291; 65862-346; 54458-862; 70518-1640; 51407-462; 51407-465; 30698-449; 68788-6889; 60760-351; 63629-8035; 70518-2125; 72189-110; 70518-0252; 71205-244; 43547-337; 50090-3243; 68071-3057; 54458-863; 68788-6957; 70518-3172; 68071-4722; 68071-5111; 63187-500; 43547-338; 70771-1150; 68071-5129; 65129-2021; 68788-9313; 70934-545; 30698-450; 71205-320; 51927-0104; 71335-0457; 65162-753; 30698-448; 42291-160; 65162-752; 65862-116; 43063-748; 22568-1136; 43063-677; 51407-464; 65162-754; 70771-1149; 58159-086; 70934-481; 70934-648; 68071-1969; 70771-1151; 70934-608; 71335-0267; 51407-463; 53002-1233; 70771-1148; 42291-161; 70934-483; 68071-5130; 63629-2679; 71335-0078; 50090-3775; 68071-4890; 64220-145; 63187-393; 50090-5751; 13612-0002; 50090-0913; 17404-0016; 43547-336; 68071-3142; 68071-3324; 43063-679; 68071-1146; 42291-162; 72969-005; 55154-4344; 63187-499; 71335-1299; 53002-1248
Synonyms benazepril | benazapril | benzazepril | Labopal | Lotensin | Cibacène | Cibacen | Briem | benazepril hydrochloride | CGS-14824-A | CGS-14824A
Chemical Information
Molecular Formula C24H29ClN2O5
CAS Registry Number 86541-74-4
SMILES CCOC(=O)C(CCC1=CC=CC=C1)NC2CCC3=CC=CC=C3N(C2=O)CC(=O)O.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Electrocardiogram abnormal13.14.05.001--Not Available
Eosinophilia01.02.04.001--
Erythema multiforme23.03.01.003; 10.01.03.015--
Face oedema23.04.01.004; 10.01.05.002; 08.01.07.003--
Fatigue08.01.01.002--
Flatulence07.01.04.002--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Gastritis07.08.02.001--
Gastrointestinal pain07.01.05.005--
Gingival hyperplasia07.09.03.002--Not Available
Gout15.01.06.001; 14.09.01.001--Not Available
Haemolytic anaemia01.06.03.002--Not Available
Headache17.14.01.001--
Hepatitis09.01.07.004--Not Available
Hyperhidrosis08.01.03.028; 23.02.03.004--
Hyperkalaemia14.05.03.001--
Hypersensitivity10.01.03.003--
Hypertonia17.05.02.001; 15.05.04.007--Not Available
Hypokalaemia14.05.03.002--
Hyponatraemia14.05.04.002--
Hypotension24.06.03.002--
Infection11.01.08.002--Not Available
Influenza22.07.02.001; 11.05.03.001--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Jaundice cholestatic09.01.01.005--Not Available
Laryngeal oedema23.04.01.005; 22.04.02.001; 10.01.05.003--
Leukopenia01.02.02.001--Not Available
Libido decreased21.03.02.005; 19.08.03.001--
Lip oedema23.04.01.006; 07.05.04.004; 10.01.05.004--Not Available
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