Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Basiliximab
Drug ID BADD_D00214
Description A recombinant chimeric (murine/human) monoclonal antibody (IgG1k) that functions as an immunosuppressive agent, specifically binding to and blocking the interleukin-2 receptor a-chain (IL-2R alpha, also known as CD25 antigen) on the surface of activated T-lymphocytes. It is a 144 kDa glycoprotein obtained from fermentation of an established mouse myeloma cell line genetically engineered to express plasmids containing the human heavy and light chain constant region genes and mouse heavy and light chain variable region genes encoding the RFT5 antibody that binds selectively to the IL-2R alpha.
Indications and Usage For prophylactic treatment of kidney transplant rejection
Marketing Status Prescription
ATC Code L04AC02
DrugBank ID DB00074
KEGG ID D03058
MeSH ID D000077552
PubChem ID Not Available
TTD Drug ID D06SBB
NDC Product Code 0078-0393; 0078-0331
Synonyms Basiliximab | Simulect | CHI 621 | SDZ CHI 621
Chemical Information
Molecular Formula Not Available
CAS Registry Number 179045-86-4
SMILES Not Available
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Drug level increased13.17.01.004--Not Available
Dyspepsia07.01.02.001--
Dyspnoea22.02.01.004; 02.01.03.002--
Dysuria20.02.02.002--
Face oedema23.04.01.004; 10.01.05.002; 08.01.07.003--
Fatigue08.01.01.002--
Flatulence07.01.04.002--
Fluid overload14.05.06.001; 02.05.04.004--Not Available
Fracture15.08.02.001; 12.04.02.001--
Gastroenteritis07.19.03.001; 11.01.07.004--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Generalised oedema14.05.06.007; 08.01.07.004--
Gingival hyperplasia07.09.03.002--Not Available
Glucocorticoids increased13.10.09.003--Not Available
Gravitational oedema08.01.07.005; 02.05.04.014--Not Available
Haematoma24.07.01.001--
Haematuria24.07.01.047; 20.02.01.006--
Headache17.14.01.001--
Heart sounds abnormal13.14.01.002--Not Available
Hernia08.01.04.001--Not Available
Herpes simplex23.09.03.001; 11.05.02.001--Not Available
Herpes zoster23.09.03.002; 11.05.02.003--
Hypercalcaemia14.04.01.003; 05.04.01.002--
Hypercholesterolaemia14.08.01.001--Not Available
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hyperkalaemia14.05.03.001--
Hypertension24.08.02.001--
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