Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Aztreonam
Drug ID BADD_D00206
Description A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.
Indications and Usage For the treatment of the following infections caused by susceptible gram-negative microorganisms: urinary tract infections, lower respiratory tract infections, septicemia, skin and skin-structure infections, intra-abdominal infections, and gynecologic infections.
Marketing Status Prescription; Discontinued
ATC Code J01DF01
DrugBank ID DB00355
KEGG ID D00240
MeSH ID D001398
PubChem ID 2274
TTD Drug ID D0F2XV
NDC Product Code 0003-2570; 61958-0901; 0409-0830; 63323-401; 13538-001; 13538-008; 24525-0025; 63323-402; 0003-2560; 0409-0829; 54087-160; 13538-009; 52952-001
Synonyms Aztreonam | Az-threonam | Az threonam | Azthreonam | SQ-26,776 | SQ 26,776 | SQ26,776 | Urobactam | Azactam
Chemical Information
Molecular Formula C13H17N5O8S2
CAS Registry Number 78110-38-0
SMILES CC1C(C(=O)N1S(=O)(=O)O)NC(=O)C(=NOC(C)(C)C(=O)O)C2=CSC(=N2)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dysgeusia17.02.07.003; 07.14.03.001--
Dyspnoea22.02.01.004; 02.01.03.0020.000745%
Eosinophil count increased13.01.06.004--Not Available
Eosinophilia01.02.04.001--
Erythema23.03.06.001--Not Available
Erythema multiforme23.03.01.003; 10.01.03.015--
Extrasystoles02.03.02.003--Not Available
Face oedema08.01.07.003; 23.04.01.004; 10.01.05.0020.000319%
Feeling abnormal08.01.09.014--Not Available
Flushing23.06.05.003; 08.01.03.025; 24.03.01.002--
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Gastrointestinal pain07.01.05.005--
Haemoglobin13.01.05.018--Not Available
Headache17.14.01.001--
Hepatic failure09.01.03.002--
Hepatitis09.01.07.004--Not Available
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypersensitivity10.01.03.003--
Hypotension24.06.03.0020.000213%
Insomnia19.02.01.002; 17.15.03.002--
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Joint swelling15.01.02.004--Not Available
Laryngeal pain22.02.05.036--
Leukocytosis01.02.01.002--
Local reaction08.01.03.012--Not Available
Malaise08.01.01.003--
Mouth ulceration07.05.06.004--Not Available
Myalgia15.05.02.001--
Nasal congestion22.04.04.001--
Nausea07.01.07.001--
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