Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Azathioprine
Drug ID BADD_D00195
Description Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection.[L11214] Azathiprine was granted FDA approval on 20 March 1968.[L11214]
Indications and Usage Azathioprine is indicated to treat rheumatoid arthritis and prevent renal transplant rejection.[L11214]
Marketing Status approved
ATC Code L04AX01
DrugBank ID DB00993
KEGG ID D00238
MeSH ID D001379
PubChem ID 2265
TTD Drug ID D07QCE
NDC Product Code 62991-2189; 65649-231; 67877-492; 68084-229; 68382-120; 51407-182; 68382-118; 72789-129; 46014-1110; 70771-1141; 60219-1076; 60219-2036; 60219-2037; 68382-003; 48954-909; 51927-0071; 68682-241; 70518-3544; 70771-1140; 51927-2258; 54766-590; 65841-602; 12780-0300; 38779-0312; 66122-0009; 42291-063; 68462-502; 71610-124; 42291-071; 68682-231; 70771-1139; 15308-0732; 49452-0783; 67877-493; 51552-0779; 65649-241; 67877-494; 67877-495; 68382-119; 42973-143
UNII MRK240IY2L
Synonyms Azathioprine | Azothioprine | Imurel | Imuran | Immuran | Azathioprine Sodium | Sodium, Azathioprine | Azathioprine Sodium Salt | Azathioprine Sulfate
Chemical Information
Molecular Formula C9H7N7O2S
CAS Registry Number 446-86-6
SMILES CN1C=NC(=C1SC2=NC=NC3=C2NC=N3)[N+](=O)[O-]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Ovarian cancer16.12.04.001; 21.11.01.0030.000313%Not Available
Ovarian cyst16.04.03.001; 21.11.01.0020.000470%Not Available
Pain08.01.08.004--
Painful respiration22.12.02.011--Not Available
Pallor24.03.04.001; 23.03.03.031; 08.01.03.032--Not Available
Pancreatic disorder07.18.02.0010.000313%Not Available
Pancreatitis07.18.01.0010.010496%
Pancreatitis acute07.18.01.0020.007363%Not Available
Pancreatitis necrotising07.18.01.0040.000313%Not Available
Pancytopenia01.03.03.0030.012532%Not Available
Panic attack19.06.04.0010.000470%Not Available
Panniculitis10.01.03.024; 23.07.02.0020.000313%Not Available
Peliosis hepatis09.01.07.0100.000627%Not Available
Pemphigoid23.03.01.004; 10.04.02.0020.000313%Not Available
Pemphigus23.03.01.005; 10.04.02.0030.000470%Not Available
Penile pain21.12.01.008--
Peptic ulcer07.04.07.001--Not Available
Periarthritis15.01.08.005--Not Available
Pericardial effusion02.06.01.0020.001410%
Pericarditis02.06.02.0010.001097%
Pharyngeal oedema23.04.01.016; 22.04.05.003; 10.01.05.0160.000313%Not Available
Phlebitis24.12.03.004; 12.02.01.002--
Photophobia17.17.02.006; 06.01.01.0040.000783%
Photosensitivity reaction23.03.09.0030.000627%
Pleural effusion22.05.02.0020.001880%
Pleurisy22.05.01.0010.000470%Not Available
Pleuritic pain22.12.01.0070.000313%
Pneumonia11.01.09.003; 22.07.01.003--Not Available
Pneumonitis22.01.01.0060.000783%
Pneumothorax22.05.02.0030.000627%
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ADReCS-Target
Drug Name ADR Term Target
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