Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apraclonidine
Drug ID BADD_D00154
Description Apraclonidine, also known as iopidine, is a sympathomimetic used in glaucoma therapy. It is an alpha2-adrenergic agonist.
Indications and Usage For prevention or reduction of intraoperative and postoperative increases in intraocular pressure (IOP) before and after ocular laser surgery when used prophylactically. Also used as a short-term adjunctive therapy in patients with open-angle glaucoma who are on maximally tolerated medical therapy requiring additional IOP reduction.
Marketing Status Prescription
ATC Code S01EA03
DrugBank ID DB00964
KEGG ID D07461
MeSH ID C016986
PubChem ID 2216
TTD Drug ID D0MT0M
NDC Product Code 61314-665
Synonyms apraclonidine | 4-aminoclonidine | para-aminoclonidine | 2-(4-amino-2,6-dichloro)phenyliminoimidazolidine | p-aminoclonidine | apraclonidine hydrochloride | Iopidine | Iopimax | ALO 2145 | ALO-2145
Chemical Information
Molecular Formula C9H10Cl2N4
CAS Registry Number 66711-21-5
SMILES C1CN=C(N1)NC2=C(C=C(C=C2Cl)N)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Eye irritation06.04.05.003--Not Available
Eye pain06.08.03.002--
Eyelid oedema23.04.01.003; 10.01.05.001; 06.04.04.004--Not Available
Eyelid ptosis17.17.02.004; 06.05.01.002--Not Available
Eyelid retraction06.06.04.002--Not Available
Face oedema23.04.01.004; 10.01.05.002; 08.01.07.003--
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Headache17.14.01.001--
Heart rate irregular13.14.04.003--Not Available
Hyperaemia24.03.02.002--Not Available
Hypersensitivity10.01.03.003--
Infection11.01.08.002--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Irritability19.04.02.013; 08.01.03.011--
Keratitis06.04.02.002--
Keratopathy06.06.03.007--Not Available
Lacrimation increased06.08.02.004--
Libido decreased21.03.02.005; 19.08.03.001--
Malaise08.01.01.003--
Myalgia15.05.02.001--
Mydriasis17.02.11.003; 06.05.03.004--Not Available
Nasal dryness22.04.03.002--Not Available
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Nervousness19.06.02.003--Not Available
Ocular hyperaemia06.04.05.004--Not Available
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