Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apixaban
Drug ID BADD_D00151
Description Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28, 2012[L6043].
Indications and Usage Apixaban is to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. It has also been used to lower the risk of developing venous thrombosis post-orthopedic surgical procedures.
Marketing Status Prescription
ATC Code B01AF02
DrugBank ID DB06605
KEGG ID D03213
MeSH ID C522181
PubChem ID 10182969
TTD Drug ID D0I5HF
NDC Product Code 0003-0893; 65129-1344; 55111-980; 50193-0893; 63629-8432; 16436-0113; 70366-001; 46708-908; 52048-0420; 63850-8085; 42816-0893; 14445-150; 59651-051; 53747-062; 65015-897; 55154-0613; 66174-0091; 76397-007; 75945-060; 24196-190; 15308-1221; 12783-0894; 66651-921; 63415-0520; 70518-1861; 66039-925; 65372-1196; 55154-0612; 12783-0893; 69989-0006; 76397-010; 42765-025; 76072-1017; 14501-0089; 67835-0015; 69037-0023; 50090-1437; 0003-0894; 58623-0137; 0003-3764; 42816-0894; 67296-1673; 58032-2028; 50090-1436; 65727-081; 14445-014; 63629-7747; 14445-149
Synonyms apixaban | Eliquis | BMS 562247 | BMS562247 | BMS-562247-01 | BMS-562247
Chemical Information
Molecular Formula C25H25N5O4
CAS Registry Number 503612-47-3
SMILES COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Clavicle fracture15.08.03.010; 12.04.01.0100.000530%Not Available
Coagulation time shortened13.01.02.0230.000265%Not Available
Coagulopathy01.01.02.0010.002650%Not Available
Cold sweat23.02.03.002; 08.01.03.024--Not Available
Colitis07.08.01.001--
Colitis ischaemic07.08.01.004; 24.04.08.0120.001590%Not Available
Colitis ulcerative10.02.01.004; 07.08.01.005--Not Available
Colon cancer16.13.01.001; 07.21.01.0010.001382%Not Available
Coma17.02.09.001--Not Available
Compartment syndrome24.04.05.006; 15.05.05.0050.000795%Not Available
Completed suicide19.12.01.001; 08.04.01.010--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Conjunctival haemorrhage24.07.05.001; 06.07.01.0010.001457%Not Available
Conjunctivitis11.01.06.012; 06.04.01.002--
Constipation07.02.02.001--
Cor pulmonale24.08.03.001; 22.06.01.003; 02.05.03.0010.000069%Not Available
Coronary artery disease02.02.01.001; 24.04.04.006--Not Available
Coronary artery occlusion24.04.04.013; 02.02.01.006--Not Available
Coronary artery stenosis24.04.04.017; 02.02.01.0100.000530%Not Available
Coronary artery thrombosis24.01.05.002; 02.02.01.007--Not Available
Cough22.02.03.001--
Creatinine renal clearance increased13.13.01.0150.000397%Not Available
Creatinine renal clearance decreased13.13.01.0130.002252%Not Available
Crohn's disease10.02.01.005; 07.08.01.015--Not Available
Cyanosis24.03.01.007; 22.02.02.007; 02.01.02.002--
Cystitis11.01.14.001; 20.03.02.002--
Cystitis haemorrhagic20.03.02.0030.000795%Not Available
Deafness04.02.01.001--Not Available
Death08.04.01.001--
Decubitus ulcer23.03.11.0060.000795%Not Available
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