Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apixaban
Drug ID BADD_D00151
Description Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28, 2012[L6043].
Indications and Usage Apixaban is to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. It has also been used to lower the risk of developing venous thrombosis post-orthopedic surgical procedures.
Marketing Status Prescription
ATC Code B01AF02
DrugBank ID DB06605
KEGG ID D03213
MeSH ID C522181
PubChem ID 10182969
TTD Drug ID D0I5HF
NDC Product Code 0003-0893; 65129-1344; 55111-980; 50193-0893; 63629-8432; 16436-0113; 70366-001; 46708-908; 52048-0420; 63850-8085; 42816-0893; 14445-150; 59651-051; 53747-062; 65015-897; 55154-0613; 66174-0091; 76397-007; 75945-060; 24196-190; 15308-1221; 12783-0894; 66651-921; 63415-0520; 70518-1861; 66039-925; 65372-1196; 55154-0612; 12783-0893; 69989-0006; 76397-010; 42765-025; 76072-1017; 14501-0089; 67835-0015; 69037-0023; 50090-1437; 0003-0894; 58623-0137; 0003-3764; 42816-0894; 67296-1673; 58032-2028; 50090-1436; 65727-081; 14445-014; 63629-7747; 14445-149
Synonyms apixaban | Eliquis | BMS 562247 | BMS562247 | BMS-562247-01 | BMS-562247
Chemical Information
Molecular Formula C25H25N5O4
CAS Registry Number 503612-47-3
SMILES COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Endocarditis11.01.16.001; 02.09.01.0010.000449%
Endometrial cancer21.07.02.002; 16.12.02.0010.000138%Not Available
Eosinophilia01.02.04.001--
Epidural anaesthesia25.01.03.004--Not Available
Epilepsy17.12.03.002--Not Available
Epistaxis24.07.01.005; 22.04.03.0010.045440%
Eructation07.01.02.003--
Erysipelas23.09.01.002; 11.02.06.0010.001855%Not Available
Erythema23.03.06.001--Not Available
Erythema multiforme23.03.01.003; 10.01.03.015--
Essential thrombocythaemia16.21.03.004; 01.13.03.0030.000265%Not Available
Exophthalmos06.09.04.001; 05.02.02.0020.000265%Not Available
Extradural haematoma12.01.10.002; 24.07.04.002; 17.08.05.0010.003047%Not Available
Eye disorder06.08.03.0010.003444%Not Available
Eye haemorrhage24.07.05.002; 06.07.02.0010.006624%Not Available
Eye pain06.08.03.002--
Eye swelling06.08.03.003--Not Available
Eyelid oedema23.04.01.003; 10.01.05.001; 06.04.04.004--Not Available
Eyelid ptosis17.17.02.004; 06.05.01.0020.000927%Not Available
Face oedema08.01.07.003; 23.04.01.004; 10.01.05.002--
Facial bones fracture15.08.04.001; 12.04.05.0020.001722%Not Available
Facial pain08.01.08.012--
Facial paralysis17.04.03.0080.001987%Not Available
Faeces discoloured07.01.03.0020.007286%Not Available
Faeces hard07.01.03.0030.000265%Not Available
Fat embolism24.01.01.012; 12.01.08.0030.000104%Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Feeling cold08.01.09.008--Not Available
Feeling hot08.01.09.009--Not Available
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