Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Apixaban
Drug ID BADD_D00151
Description Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28, 2012[L6043].
Indications and Usage Apixaban is indicated for reducing the risk of stroke and systemic embolism in patients who have nonvalvular atrial fibrillation, prophylaxis of deep vein thrombosis(DVT) leading to pulmonary embolism(PE) in patients after a hip or knee replacement surgery, and treatment of DVT and PE to reduce the risk of recurrence[Label,A177565,A6897].
Marketing Status approved
ATC Code B01AF02
DrugBank ID DB06605
KEGG ID D03213
MeSH ID C522181
PubChem ID 10182969
TTD Drug ID D0I5HF
NDC Product Code 0003-0893; 52048-0420; 69037-0023; 76397-007; 15308-1221; 24196-190; 58032-2028; 66174-0091; 50193-0893; 65372-1196; 65727-081; 0003-3764; 55154-0612; 59651-051; 70366-001; 14445-149; 12783-0893; 12783-0894; 17381-026; 42765-025; 42816-0894; 58623-0137; 63850-8085; 65129-1344; 66039-925; 66651-921; 69989-0006; 63629-7747; 12658-0440; 53869-0893; 73377-191; 55154-0613; 70518-1861; 71610-662; 67835-0015; 75945-060; 76397-010; 50090-6454; 82982-054; 14501-0089; 16436-0113; 65129-1465; 63629-8432; 14445-014; 53747-062; 53869-0894; 63415-0520; 65015-897; 76072-1017; 14445-150; 42816-0893; 0003-0894; 55111-980; 50090-6451
UNII 3Z9Y7UWC1J
Synonyms apixaban | Eliquis | BMS 562247 | BMS562247 | BMS-562247-01 | BMS-562247
Chemical Information
Molecular Formula C25H25N5O4
CAS Registry Number 503612-47-3
SMILES COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Osteoarthritis15.01.04.0010.000625%Not Available
Osteoporosis15.02.03.002; 14.04.04.002--
Ovarian cancer21.11.01.003; 16.12.04.0010.000239%Not Available
Pallor24.03.04.001; 23.03.03.031; 08.01.03.032--Not Available
Pancreatitis acute07.18.01.002--Not Available
Papilloma16.02.02.0040.000043%Not Available
Paralysis17.01.04.0040.000390%Not Available
Paraparesis17.01.04.0060.000043%Not Available
Paraplegia17.01.04.0070.000217%Not Available
Paresis17.01.04.0080.000108%Not Available
Pelvic venous thrombosis24.01.02.0080.000217%Not Available
Pemphigoid23.03.01.004; 10.04.02.0020.000325%Not Available
Penile haemorrhage24.07.03.018; 21.12.01.0110.000139%Not Available
Peptic ulcer07.04.07.0010.000260%Not Available
Peptic ulcer haemorrhage24.07.02.015; 07.04.07.0020.000043%Not Available
Pericardial effusion02.06.01.0020.001193%
Pericardial haemorrhage24.07.01.013; 02.06.01.0030.001714%Not Available
Pericarditis02.06.02.0010.000347%
Pericarditis constrictive02.06.02.0020.000043%Not Available
Periorbital haematoma23.03.11.001; 12.01.04.013; 06.07.02.004; 24.07.05.008--Not Available
Peripheral ischaemia24.04.03.0020.000217%
Peripheral vascular disorder24.03.01.0030.000204%Not Available
Petechiae24.07.06.004; 23.06.01.003; 01.01.03.0020.002356%Not Available
Pharyngeal haemorrhage24.07.02.017; 22.04.05.0020.000130%
Phlebitis12.02.01.002; 24.12.03.0040.000733%
Pleural effusion22.05.02.002--
Pleuritic pain22.12.01.0070.000065%
Polyarthritis15.01.01.0050.000087%Not Available
Polycythaemia vera01.13.03.002; 16.21.03.0030.000043%Not Available
Polymyalgia rheumatica15.06.01.001; 10.04.05.0030.000065%Not Available
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