Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Amoxicillin
Drug ID BADD_D00129
Description Amoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972.[A190648] Amoxicillin has similar activity to [penicillin] and [ampicillin], but leads to higher serum concentrations than ampicillin.[A190648] Amoxicillin was granted FDA approval on 18 January 1974.[L11644]
Indications and Usage For the treatment of infections of the ear, nose, and throat, the genitourinary tract, the skin and skin structure, and the lower respiratory tract due to susceptible (only b-lactamase-negative) strains of Streptococcus spp. (a- and b-hemolytic strains only), S. pneumoniae, Staphylococcus spp., H. influenzae, E. coli, P. mirabilis, or E. faecalis. Also for the treatment of acute, uncomplicated gonorrhea (ano-genital and urethral infections) due to N. gonorrhoeae (males and females).
Marketing Status Prescription; Discontinued
ATC Code J01CA04
DrugBank ID DB01060
KEGG ID D00229
MeSH ID D000658
PubChem ID 33613
TTD Drug ID D0F6EO
NDC Product Code 16714-299; 63187-729; 68071-2323; 67296-1126; 70882-114; 63187-335; 50090-0407; 70518-1413; 70934-672; 50090-1826; 65862-016; 72789-225; 72789-077; 63187-186; 72189-285; 55657-106; 0093-3109; 68071-1526; 68071-4734; 45865-594; 65862-707; 68788-9949; 68071-1675; 50090-1794; 67296-1659; 61919-716; 68071-1817; 70847-530; 70882-113; 61919-041; 63187-044; 16714-298; 68071-4548; 50090-4260; 72508-205; 68071-2364; 63187-043; 68788-7318; 68071-4953; 65862-014; 50090-1797; 68071-2397; 65862-071; 52115-001; 65862-015; 0143-9889; 63187-200; 50090-4929; 63629-7585; 57237-033; 50090-1513; 70518-2191; 68071-4851; 68071-4704; 0143-9887; 50090-2251; 0781-5061; 63187-343; 0143-9886; 55289-182; 68071-4920; 70518-2188; 53002-1369; 68071-4567; 68071-4982; 50090-4320; 43063-820; 70934-064; 53002-2160; 0143-9888; 65862-274; 63629-7582; 71205-266; 63629-7584; 0093-4160; 50090-1795; 66267-871; 50090-0404; 0093-4161; 53002-0130; 50090-1807; 68071-1760; 0143-9938; 59115-041; 0143-9939; 68071-4907; 71205-507; 68788-7414; 76420-003; 65862-706; 0781-6156; 67296-1156; 68071-5019; 68071-4064; 63187-262; 68071-4455; 63187-195; 70518-3234; 43063-341; 68071-4574; 0781-5060; 72789-075; 61919-401; 65862-017; 68071-5127; 0781-6041; 57237-028; 43063-563; 68788-9017; 53002-2091; 70518-2190; 50090-0713; 63187-027; 68071-3292; 68071-4698; 68071-2604; 50090-3516; 43063-915; 70518-3228; 50090-1086; 63629-7587; 50090-1347; 53002-2080; 0093-2264; 70847-550; 68788-9948; 68071-2423; 63187-029; 68788-6374; 0093-2267; 68071-2558; 71205-422; 0781-6157; 70518-3294; 42708-112; 50090-1511; 50090-0712; 50090-1796; 55289-020; 43063-574; 50090-0709; 72789-074; 50090-0858; 68071-1789; 57237-030; 68071-4468; 68071-1761; 68071-3343; 63629-7589; 68071-4581; 70934-054; 70934-038; 70934-033; 0781-2613; 42708-078; 70934-087; 57237-031; 61919-015; 0093-3107; 54348-550; 55657-101; 61919-623; 72789-078; 63187-399; 66267-993; 68788-9019; 55289-019; 0781-2020; 71205-035; 42708-076; 68071-2320; 50090-0301; 71205-177; 50090-1595; 76420-138; 0093-2268; 53002-2090; 50090-1512; 0143-9285; 61919-994; 72789-224; 50090-1596; 68071-5148; 68788-7141; 68071-4971; 50090-0303; 66267-994; 50090-0405; 63187-880; 71205-436; 68071-4086; 0093-2263; 42708-010; 70934-140; 68788-6369; 61919-135; 50090-5863; 68788-9018; 57237-029; 50090-0455; 61919-672; 70934-084; 76420-192; 68071-4969; 65862-070; 72508-225; 70934-310; 68071-5096; 68071-5109; 50090-4078; 59651-099; 67296-0986; 68071-4741; 50090-5880; 63629-7588; 50090-4325; 70934-154; 50090-0711; 63187-013; 63187-295; 68071-4796; 43063-885; 0093-4155; 76420-112; 50090-0714; 57237-032; 63187-325; 68071-4693; 50090-0406; 43063-017; 68788-7812; 0781-6039; 50090-1514; 63187-591; 70934-407; 68071-3119; 50090-5215; 50090-0411; 68071-1826; 68071-4724; 68788-7323; 50090-0288; 68071-4696
Synonyms Amoxicillin | Amoxycillin | Amoxicilline | Amoxicillin Monopotassium Salt | Hydroxyampicillin | Amoxicillin Sodium | Amoxicillin Monosodium Salt | Amoxicillin, (R*)-Isomer | Amoxicillin Anhydrous | Actimoxi | BRL-2333 | BRL 2333 | BRL2333 | Clamoxyl | Penamox | Clamoxyl Parenteral | Clamoxyl G.A. | Polymox | Trimox | Wymox | Amoxicillin Trihydrate | Amoxil
Chemical Information
Molecular Formula C16H19N3O5S
CAS Registry Number 26787-78-0
SMILES CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)C(=O)O)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
HyperphosphatasaemiaC-C chemokine receptor type 4P51679T0695525998949
HyperphosphatasaemiaC-X-C chemokine receptor type 3P49682T2531525998949
HyperphosphatasaemiaC-C chemokine receptor type 9P51686T9787325998949
Liver injuryC-C chemokine receptor type 4P51679T0695525998949
Liver injuryC-X-C chemokine receptor type 3P49682T2531525998949
Liver injuryC-C chemokine receptor type 9P51686T9787325998949
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Clostridium difficile colitis11.02.02.004; 07.19.01.0040.000131%Not Available
Coagulopathy01.01.02.001--Not Available
Cold sweat23.02.03.002; 08.01.03.0240.000061%Not Available
Colitis07.08.01.001--
Colitis ulcerative10.02.01.004; 07.08.01.0050.000040%Not Available
Coma17.02.09.001--Not Available
Completed suicide19.12.01.001; 08.04.01.010--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Conjunctivitis11.01.06.012; 06.04.01.0020.000131%
Constipation07.02.02.001--
Coordination abnormal17.02.02.0040.000030%Not Available
Coronary artery thrombosis24.01.05.002; 02.02.01.0070.000008%Not Available
Cough22.02.03.001--
Crepitations08.01.03.0060.000020%Not Available
Crohn's disease10.02.01.005; 07.08.01.015--Not Available
Crying19.04.02.002; 17.02.05.013; 12.02.11.001; 08.01.03.005--Not Available
Cryptorchism03.03.01.001; 21.15.01.001; 05.05.02.0020.000030%Not Available
Crystalluria20.02.01.0030.000161%Not Available
Crystal urine present13.13.02.0150.000020%Not Available
Cyanosis24.03.01.007; 22.02.02.007; 02.01.02.0020.000071%
Cytomegalovirus hepatitis11.05.01.009; 09.01.09.0090.000020%Not Available
Deafness04.02.01.0010.000061%Not Available
Deafness neurosensory04.02.01.002; 17.04.07.0010.000020%Not Available
Death08.04.01.001--
Defaecation urgency07.02.04.0010.000020%Not Available
Dehydration14.05.05.001--
Delirium19.13.02.001--
Depressed level of consciousness17.02.04.002--
Depressed mood19.15.02.001--Not Available
Depression19.15.01.001--
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