| Drug Name |
Amisulpride |
| Drug ID |
BADD_D00117 |
| Description |
Amisulpride is a benzamide derivative and a dopamine receptor antagonist that selectively works on dopamine D2 and D3 receptors. As an antipsychotic agent, amisulpride alleviates both positive and negative symptoms of schizophrenia, and it exhibits antidepressant properties in patients with psychiatric disorders, dysthymia, and major depression.[A6755] Amisulpride predominantly works in the limbic system, which explains its relatively lower risk of extrapyramidal adverse effects compared to other atypical antipsychotic agents.[A6752, L32764] Oral tablets of amisulpride is used in European countries as a treatment for acute and chronic schizophrenic disorders, as well as secondary negative symptoms in mental health disorders such as affective disorders, depressive mood, and mental retardation.[L32764]
Amisulpride is also used as an antiemetic agent. In the US, the intravenous formulation of amisulpride is used to treat and prevent postoperative nausea and vomiting in adults, either as monotherapy or in combination with another antiemetic agent of a different drug class.[L32759] It is marketed under the brand name Barhemsys. |
| Indications and Usage |
Investigated for use/treatment in schizophrenia and schizoaffective disorders, mania in bipolar disorder, and depression. |
| Marketing Status |
Not Available |
| ATC Code |
N05AL05 |
| DrugBank ID |
DB06288
|
| KEGG ID |
D07310
|
| MeSH ID |
D000077582
|
| PubChem ID |
2159
|
| TTD Drug ID |
D03ELL
|
| NDC Product Code |
71390-125; 51604-1156 |
| Synonyms |
Amisulpride | 4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide | DAN 2163 | DAN-2163 | Solian | Sultopride | N-(Ethyl-1-pyrrolidinyl- 2-methyl)methoxy-2-ethylsulfonyl-5-benzamide | LIN 1418 | LIN-1418 | Barnetil | Sultopride Hydrochloride |
