Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Amantadine hydrochloride
Drug ID BADD_D00098
Description An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake.
Indications and Usage For the chemoprophylaxis, prophylaxis, and treatment of signs and symptoms of infection caused by various strains of influenza A virus. Also for the treatment of parkinsonism and drug-induced extrapyramidal reactions.
Marketing Status Prescription; Discontinued
ATC Code N04BB01
DrugBank ID DB00915
KEGG ID D00777
MeSH ID D000547
PubChem ID 64150
TTD Drug ID D08MCS
NDC Product Code 53002-3750; 70859-012; 0395-8058; 71335-0469; 42543-497; 23155-362; 42291-125; 51927-1754; 17856-0646; 0904-6630; 50268-069; 0121-0646; 10888-8149; 73152-075; 69097-925; 0591-4930; 61474-4269; 10135-693; 52932-0707; 0615-8263; 17373-1446; 24689-112; 71205-223; 50090-0020; 72888-033; 71335-0279; 0904-7042; 65841-835; 49452-0395; 60687-239; 24689-105; 0527-1704; 0591-4920; 63818-0435; 70518-3381; 10695-014; 50383-807; 0832-0111; 10135-692; 66653-003; 55154-9444; 0832-1015; 62991-2559; 60432-093; 73152-076; 59746-699; 68382-512; 38779-0411; 69097-926; 69452-142; 42543-493
Synonyms Amantadine | 1-Aminoadamantane | 1 Aminoadamantane | Adamantylamine | Wiregyt | Amanta | Amanta-HCI-AZU | Amanta HCI AZU | AmantaHCIAZU | Amanta-Sulfate-AZU | Amanta Sulfate AZU | AmantaSulfateAZU | Amantadin AZU | AZU, Amantadin | Amantadin AL | AL, Amantadin | Amantadin Stada | Stada, Amantadin | Amantadin-neuraxpharm | Amantadin neuraxpharm | Amantadinneuraxpharm | Amantadin-ratiopharm | Amantadin ratiopharm | Amantadinratiopharm | Amantadina Juventus | Juventus, Amantadina | Amantadina Llorente | Llorente, Amantadina | Amantadine Hydrochloride | Hydrochloride, Amantadine | Amantadine Sulfate | Sulfate, Amantadine | Amixx | Cerebramed | Gen-Amantadine | Gen Amantadine | GenAmantadine | Infecto-Flu | Infecto Flu | InfectoFlu | Infex | Midantan | PMS-Amantadine | PMS Amantadine | PMSAmantadine | Symadine | Symmetrel | Endantadine | Mantadix | tregor | Viregyt | Adekin | Aman
Chemical Information
Molecular Formula C10H18ClN
CAS Registry Number 665-66-7
SMILES C1C2CC3CC1CC(C2)(C3)N.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry mouth07.06.01.002--
Dysarthria17.02.08.001; 19.19.03.001--
Dysphagia07.01.06.003--
Dyspnoea22.02.01.004; 02.01.03.002--
Eczema23.03.04.006--
Electroencephalogram abnormal13.07.03.001--Not Available
Euphoric mood19.04.02.006--
Fatigue08.01.01.002--
Gait disturbance17.02.05.016; 08.01.02.002--
Gamma-glutamyltransferase increased13.03.01.011--
Hallucination19.10.02.002--
Headache17.14.01.001--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hyperkinesia17.01.02.008--Not Available
Hypertension24.08.02.001--
Hypertonia17.05.02.001; 15.05.04.007--Not Available
Hypokinesia17.01.02.009--Not Available
Hypotension24.06.03.002--
Insomnia19.02.01.002; 17.15.03.002--
Irritability19.04.02.013; 08.01.03.011--
Keratitis06.04.02.002--
Leukocytosis01.02.01.002--
Leukopenia01.02.02.001--Not Available
Libido decreased21.03.02.005; 19.08.03.001--
Livedo reticularis24.03.04.003; 23.06.05.001--Not Available
Mania19.16.02.002--
Muscle contractions involuntary17.05.03.001; 15.05.03.008--Not Available
Mydriasis17.02.11.003; 06.05.03.004--Not Available
Nasal dryness22.04.03.002--Not Available
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