Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Amantadine
Drug ID BADD_D00097
Description An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake.
Indications and Usage For the chemoprophylaxis, prophylaxis, and treatment of signs and symptoms of infection caused by various strains of influenza A virus. Also for the treatment of parkinsonism and drug-induced extrapyramidal reactions.
Marketing Status Prescription; Discontinued
ATC Code N04BB01
DrugBank ID DB00915
KEGG ID D07441
MeSH ID D000547
PubChem ID 2130
TTD Drug ID D02KRS
NDC Product Code 62332-246; 68025-076; 70482-085; 70482-170; 68025-075; 60687-422; 70482-075; 11014-0234; 46708-246; 11014-0245; 68025-074; 70482-076; 62332-586; 46708-586
Synonyms Amantadine | 1-Aminoadamantane | 1 Aminoadamantane | Adamantylamine | Wiregyt | Amanta | Amanta-HCI-AZU | Amanta HCI AZU | AmantaHCIAZU | Amanta-Sulfate-AZU | Amanta Sulfate AZU | AmantaSulfateAZU | Amantadin AZU | AZU, Amantadin | Amantadin AL | AL, Amantadin | Amantadin Stada | Stada, Amantadin | Amantadin-neuraxpharm | Amantadin neuraxpharm | Amantadinneuraxpharm | Amantadin-ratiopharm | Amantadin ratiopharm | Amantadinratiopharm | Amantadina Juventus | Juventus, Amantadina | Amantadina Llorente | Llorente, Amantadina | Amantadine Hydrochloride | Hydrochloride, Amantadine | Amantadine Sulfate | Sulfate, Amantadine | Amixx | Cerebramed | Gen-Amantadine | Gen Amantadine | GenAmantadine | Infecto-Flu | Infecto Flu | InfectoFlu | Infex | Midantan | PMS-Amantadine | PMS Amantadine | PMSAmantadine | Symadine | Symmetrel | Endantadine | Mantadix | tregor | Viregyt | Adekin | Aman
Chemical Information
Molecular Formula C10H17N
CAS Registry Number 768-94-5
SMILES C1C2CC3CC1CC(C2)(C3)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Irritability08.01.03.011; 19.04.02.013--
Keratitis06.04.02.002--
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.008--
Leukocytosis01.02.01.002--
Leukopenia01.02.02.001--Not Available
Libido decreased19.08.03.001; 21.03.02.005--
Libido increased21.03.02.007; 19.08.03.002--
Livedo reticularis24.03.04.003; 23.06.05.0010.001802%Not Available
Liver function test abnormal13.03.01.013--Not Available
Mania19.16.02.002--
Mental disability26.01.01.001--Not Available
Mental impairment17.03.03.002; 19.21.02.003--Not Available
Muscle contractions involuntary17.05.03.001; 15.05.03.008--Not Available
Mydriasis17.02.11.003; 06.05.03.004--Not Available
Myoclonus17.02.05.0080.002702%Not Available
Nasal dryness22.04.03.002--Not Available
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Nervousness19.06.02.003--Not Available
Neuroleptic malignant syndrome17.05.02.003; 15.05.04.015; 12.03.01.003; 08.05.01.005--Not Available
Neutropenia01.02.03.004--Not Available
Nightmare19.02.03.003--Not Available
Oculogyric crisis06.05.02.002; 17.01.03.002--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Osteoarthritis15.01.04.001--Not Available
Palpitations02.01.02.003--
Paraesthesia17.02.06.005--
Paralysis17.01.04.004--Not Available
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