Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Amantadine
Drug ID BADD_D00097
Description An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake.
Indications and Usage For the chemoprophylaxis, prophylaxis, and treatment of signs and symptoms of infection caused by various strains of influenza A virus. Also for the treatment of parkinsonism and drug-induced extrapyramidal reactions.
Marketing Status Prescription; Discontinued
ATC Code N04BB01
DrugBank ID DB00915
KEGG ID D07441
MeSH ID D000547
PubChem ID 2130
TTD Drug ID D02KRS
NDC Product Code 62332-246; 68025-076; 70482-085; 70482-170; 68025-075; 60687-422; 70482-075; 11014-0234; 46708-246; 11014-0245; 68025-074; 70482-076; 62332-586; 46708-586
Synonyms Amantadine | 1-Aminoadamantane | 1 Aminoadamantane | Adamantylamine | Wiregyt | Amanta | Amanta-HCI-AZU | Amanta HCI AZU | AmantaHCIAZU | Amanta-Sulfate-AZU | Amanta Sulfate AZU | AmantaSulfateAZU | Amantadin AZU | AZU, Amantadin | Amantadin AL | AL, Amantadin | Amantadin Stada | Stada, Amantadin | Amantadin-neuraxpharm | Amantadin neuraxpharm | Amantadinneuraxpharm | Amantadin-ratiopharm | Amantadin ratiopharm | Amantadinratiopharm | Amantadina Juventus | Juventus, Amantadina | Amantadina Llorente | Llorente, Amantadina | Amantadine Hydrochloride | Hydrochloride, Amantadine | Amantadine Sulfate | Sulfate, Amantadine | Amixx | Cerebramed | Gen-Amantadine | Gen Amantadine | GenAmantadine | Infecto-Flu | Infecto Flu | InfectoFlu | Infex | Midantan | PMS-Amantadine | PMS Amantadine | PMSAmantadine | Symadine | Symmetrel | Endantadine | Mantadix | tregor | Viregyt | Adekin | Aman
Chemical Information
Molecular Formula C10H17N
CAS Registry Number 768-94-5
SMILES C1C2CC3CC1CC(C2)(C3)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Disorientation19.13.01.002; 17.02.05.015--Not Available
Disturbance in attention19.21.02.002; 17.03.03.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.0040.005405%
Drug hypersensitivity10.01.01.0010.001802%Not Available
Drug withdrawal syndrome08.06.02.004; 19.07.02.0110.001802%Not Available
Dry mouth07.06.01.0020.002702%
Dysarthria19.19.03.001; 17.02.08.001--
Dyskinesia17.01.02.0060.002702%
Dyspepsia07.01.02.001--
Dysphagia07.01.06.003--
Dyspnoea22.02.01.004; 02.01.03.002--
Eczema23.03.04.006--
Euphoric mood19.04.02.006--
Eye disorder06.08.03.001--Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Gait disturbance17.02.05.016; 08.01.02.002--
Gastrointestinal disorder07.11.01.001--Not Available
Hallucination19.10.02.0020.009909%
Hallucination, visual19.10.02.0040.001802%Not Available
Headache17.14.01.001--
Hyperhidrosis08.01.03.028; 23.02.03.004--
Hyperkinesia17.01.02.008--Not Available
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypertonia17.05.02.001; 15.05.04.007--Not Available
Hypokinesia17.01.02.009--Not Available
Hypotension24.06.03.002--
Hypothermia12.05.03.001; 08.05.01.003--
Insomnia19.02.01.002; 17.15.03.0020.005405%
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