Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alendronic acid
Drug ID BADD_D00066
Description Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].
Indications and Usage For the treatment and prevention of osteoporosis in women and Paget's disease of bone in both men and women.
Marketing Status Prescription; Discontinued
ATC Code M05BA04
DrugBank ID DB00630
KEGG ID D07119
MeSH ID D019386
PubChem ID 2088
TTD Drug ID D09KLR
NDC Product Code Not Available
Synonyms Alendronate | 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate | Aminohydroxybutane Bisphosphonate | MK-217 | MK 217 | MK217 | Alendronate Monosodium Salt, Trihydrate | Alendronate Sodium | Fosamax
Chemical Information
Molecular Formula C4H13NO7P2
CAS Registry Number 66376-36-1
SMILES C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Bone pain15.02.01.0010.005153%
Bradycardia02.03.02.0020.001920%Not Available
Breast cancer21.05.01.003; 16.10.01.0010.004749%Not Available
Breast cyst21.05.01.006; 16.14.01.0040.000707%Not Available
Breast disorder female21.05.04.0070.000202%Not Available
Breast enlargement21.05.04.0010.000202%Not Available
Breast hyperplasia21.05.01.0070.000202%Not Available
Breast mass21.05.04.0020.002324%Not Available
Breast pain21.05.05.0030.000303%
Breath odour07.01.06.0020.000202%Not Available
Bronchiectasis22.03.02.0050.000202%Not Available
Bronchitis22.07.01.001; 11.01.09.0010.007174%
Bronchitis chronic22.03.01.0190.000808%Not Available
Bronchospasm22.03.01.004; 10.01.03.0120.000606%
Bruxism19.11.03.001; 07.01.06.0080.000808%Not Available
Bundle branch block left02.03.01.0070.002021%Not Available
Bundle branch block right02.03.01.0110.000808%Not Available
Burning sensation17.02.06.001; 08.01.09.029--Not Available
Bursitis15.04.01.0010.014953%Not Available
C-reactive protein increased13.09.01.007--Not Available
Cachexia16.32.03.011; 14.03.02.001; 08.01.01.0090.000053%Not Available
Calcinosis08.03.04.0020.000404%Not Available
Calcium deficiency14.04.01.013; 05.04.02.0040.004850%Not Available
Calculus urinary20.04.02.0010.000202%Not Available
Cardiac arrest02.03.04.001--
Cardiac failure02.05.01.001--
Cardiac failure congestive02.05.01.0020.005355%Not Available
Cardiac murmur13.14.01.0010.005961%Not Available
Cardio-respiratory arrest22.02.06.007; 02.03.04.002--Not Available
Cardiomegaly02.04.02.0010.000791%Not Available
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