Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alendronic acid
Drug ID BADD_D00066
Description Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].
Indications and Usage For the treatment and prevention of osteoporosis in women and Paget's disease of bone in both men and women.
Marketing Status Prescription; Discontinued
ATC Code M05BA04
DrugBank ID DB00630
KEGG ID D07119
MeSH ID D019386
PubChem ID 2088
TTD Drug ID D09KLR
NDC Product Code Not Available
Synonyms Alendronate | 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate | Aminohydroxybutane Bisphosphonate | MK-217 | MK 217 | MK217 | Alendronate Monosodium Salt, Trihydrate | Alendronate Sodium | Fosamax
Chemical Information
Molecular Formula C4H13NO7P2
CAS Registry Number 66376-36-1
SMILES C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Angina unstable24.04.04.004; 02.02.02.0040.000303%Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Angle closure glaucoma06.03.01.0010.000202%Not Available
Anhedonia19.15.02.0070.003435%Not Available
Ankle fracture15.08.03.005; 12.04.01.0050.006668%
Anxiety19.06.02.0020.026875%
Aortic aneurysm24.02.03.0010.000505%Not Available
Aortic stenosis24.04.01.0010.001718%Not Available
Aortic valve incompetence02.07.03.0010.001718%Not Available
Aortic valve sclerosis02.07.03.0030.000404%Not Available
Aphasia19.21.01.001; 17.02.03.001--
Aphonia22.02.05.024; 19.19.01.002; 17.02.08.0090.000202%
Aphthous ulcer07.05.06.0020.000707%Not Available
Apnoea22.02.01.0010.000202%
Appendicitis11.01.07.001; 07.19.01.0010.000505%
Arrhythmia02.03.02.0010.002425%Not Available
Arrhythmia supraventricular02.03.03.0010.000303%Not Available
Arteriosclerosis24.04.02.0010.000580%Not Available
Arteriosclerosis coronary artery24.04.04.012; 02.02.01.0110.000580%Not Available
Arthralgia15.01.02.0010.029098%
Arthritis15.01.01.0010.017176%
Arthropathy15.01.01.0030.013337%Not Available
Aspartate aminotransferase increased13.03.01.006--
Aspiration22.02.07.0070.000105%
Aspiration pleural cavity13.19.03.0020.000303%Not Available
Asthenia08.01.01.0010.007376%Not Available
Asthma22.03.01.002; 10.01.03.0100.007982%Not Available
Ataxia08.01.02.004; 17.02.02.0010.000808%
Atelectasis22.01.02.0010.003738%
Atrial fibrillation02.03.03.0020.005658%
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