Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alemtuzumab
Drug ID BADD_D00064
Description Humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein,CD52. The Campath-1H antibody is an IgG1 kappa with human variable framework and constant regions, and complementarity-determining regions from a murine (rat) monoclonal antibody (Campath-1G). Campath is produced in mammalian cell (Chinese hamster ovary) suspension culture in a medium containing neomycin.
Indications and Usage Alemtuzumab (Campath) is a monoclonal antibody therapy used for treatment of B-cell chronic lymphocytic leukemia.
Marketing Status Prescription
ATC Code L04AA34
DrugBank ID DB00087
KEGG ID D02802
MeSH ID D000074323
PubChem ID Not Available
TTD Drug ID D01ZYG
NDC Product Code 58468-0200; 58468-0357
Synonyms Alemtuzumab | Campath 1H | Monoclonal Antibody Campath-1H | Antibody Campath-1H, Monoclonal | Campath-1H, Monoclonal Antibody | Monoclonal Antibody Campath 1H | Campath-1H | Campath1H | Campath 1M | Campath-1M | MabCambath | Lemtrada | Campath 1G | Campath-1-G | Campath 1 G | Campath1G | Campath-1G | Campath
Chemical Information
Molecular Formula Not Available
CAS Registry Number 216503-57-0
SMILES Not Available
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Neutropenia01.02.03.004--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Pain in extremity15.03.04.010--
Paraesthesia17.02.06.005--
Parathyroid disorder05.04.03.001--Not Available
Progressive multifocal leukoencephalopathy17.16.02.002; 11.05.05.001--Not Available
Pruritus23.03.12.001--
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Respiratory arrest22.02.01.009--Not Available
Sepsis11.01.11.003--
Serum sickness12.02.08.004; 10.01.03.004--
Sinusitis22.07.03.007; 11.01.13.005--
Suicidal ideation19.12.01.003--
Syncope24.06.02.012; 17.02.04.008; 02.01.02.008--
Tachycardia02.03.02.007--Not Available
Thrombocytopenia01.08.01.002--Not Available
Transfusion reaction10.02.04.001; 01.05.01.005; 12.02.08.001--Not Available
Tremor17.01.06.002--
Tumour lysis syndrome16.32.03.002; 14.05.01.004--
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
Urinary tract infection20.08.02.001; 11.01.14.004--
Urticaria10.01.06.001; 23.04.02.001--
Viral infection11.05.04.001--Not Available
Vomiting07.01.07.003--
Ejection fraction decreased13.14.02.003--
T-lymphocyte count decreased13.01.06.049--Not Available
Chronic inflammatory demyelinating polyradiculoneuropathy17.09.04.004; 10.04.10.004--Not Available
Cytomegalovirus viraemia11.05.01.003--Not Available
Lymphoproliferative disorder16.21.02.001; 01.13.02.001--Not Available
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