Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Acitretin
Drug ID BADD_D00036
Description An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate.
Indications and Usage Zouboulis CC: Retinoids--which dermatological indications will benefit in the near future? Skin Pharmacol Appl Skin Physiol. 2001 Sep-Oct;14(5):303-15.
Marketing Status Prescription; Discontinued
ATC Code D05BB02
DrugBank ID DB00459
KEGG ID D02754
MeSH ID D017255
PubChem ID 5284513
TTD Drug ID D05QDC
NDC Product Code 42291-088; 0145-0091; 17337-0004; 76055-0001; 71214-0668; 0093-1136; 0093-1135; 58159-058; 42794-081; 42794-080; 0093-1138; 0145-0090; 62147-0145; 42794-083; 42291-086; 71214-0667; 71214-0669; 0378-7020; 0115-1750; 0115-1751; 0115-1752; 71214-0698; 42291-087; 62147-0146; 0378-7023; 17337-0003; 59981-011; 0115-1753
Synonyms Acitretin | Etretin | Isoacitretin | Isoetretin | Ro 10-1670 | Ro 101670 | Ro-10-1670 | Ro101670 | 13-cis-Acitretin | Neotigason | Soriatane | Acitretin, (Z,E,E,E)-Isomer | Ro-13-7652 | Ro137652 | Ro 13-7652 | Ro 137652
Chemical Information
Molecular Formula C21H26O3
CAS Registry Number 55079-83-9
SMILES CC1=CC(=C(C(=C1C=CC(=CC=CC(=CC(=O)O)C)C)C)C)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Laboratory test abnormal13.18.01.001--Not Available
Lacrimation disorder06.08.02.010--Not Available
Laryngitis22.07.03.001; 11.01.13.001--
Libido decreased21.03.02.005; 19.08.03.001--
Lip dry07.06.01.0030.008592%Not Available
Lipids increased13.12.02.0040.005728%Not Available
Liver function test abnormal13.03.01.013--Not Available
Lymphocyte count decreased13.01.06.006--
Lymphocyte count increased13.01.06.007--
Macule23.03.03.0370.005728%Not Available
Malaise08.01.01.003--
Mass08.03.05.003--Not Available
Melaena24.07.02.013; 07.12.02.004--Not Available
Menopausal symptoms21.02.02.002--Not Available
Migraine17.14.02.001; 24.03.05.003--Not Available
Monocyte count decreased13.01.06.008--Not Available
Monocyte count increased13.01.06.009--Not Available
Mouth ulceration07.05.06.004--Not Available
Muscle spasms15.05.03.004--
Muscular weakness17.05.03.005; 15.05.06.001--
Myalgia15.05.02.0010.008592%
Mycosis fungoides23.07.04.008; 16.17.03.001; 01.11.03.0010.002241%Not Available
Myopathy15.05.05.001--Not Available
Nail disorder23.02.05.002--
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Neuritis17.09.03.001--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Neutrophil count decreased13.01.06.010--
Neutrophil count increased13.01.06.011--Not Available
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