Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Acetylcysteine
Drug ID BADD_D00032
Description Acetylcysteine is an antioxidant and glutathione inducer indicated for mucolytic therapy and the treatment of [acetaminophen] overdose.[L31378,L31383,L31388,L31478] Acetylcysteine has also been studied for a wide variety of off-label indications with mixed results.[A228158,A228163,A228168] Acetylcysteine was granted FDA approval on 14 September 1963.[L31488]
Indications and Usage Acetylcysteine is indicated for mucolytic therapy and in the management of [acetaminophen] overdose.[L31378,L31383,L31388,L31478]
Marketing Status approved; investigational
ATC Code R05CB01; S01XA08; V03AB23
DrugBank ID DB06151
KEGG ID D00221
MeSH ID D000111
PubChem ID 12035
TTD Drug ID D06XGW
NDC Product Code 70594-111; 12598-7311; 49452-0098; 51552-0201; 51927-1601; 63323-694; 70710-1015; 55150-259; 66220-207; 0517-7610; 55154-5731; 12598-7302; 12598-7308; 12598-7323; 14445-412; 63323-963; 0409-3307; 0517-7504; 0517-7630; 72611-860; 83270-001; 25021-812; 63323-693; 63323-695; 0409-3308; 0517-7604; 17478-660; 63323-690; 63323-692; 0517-7510; 70771-1412; 52932-0704; 63323-691; 12598-7027; 52951-001; 0574-0805; 12598-7294; 12598-7327; 52133-0002; 52932-0742; 55154-5730
UNII WYQ7N0BPYC
Synonyms Acetylcysteine | N-Acetyl-L-cysteine | N Acetyl L cysteine | N-Acetylcysteine | N Acetylcysteine | Mercapturic Acid | Acid, Mercapturic | Solmucol | Genac | Acemuc | Acetabs | Acetylcystein AL | NAC AL | Acetylcystein Atid | Acetylcystein Heumann | Acetylcystein Trom | Acetylcysteine Hydrochloride | Hydrochloride, Acetylcysteine | Acetylcysteine Sodium | Sodium, Acetylcysteine | Acetylcysteine, Monosodium Salt | Monosodium Salt Acetylcysteine | Acetylcysteine Zinc | Zinc, Acetylcysteine | Acetylcysteine, (D)-Isomer | Acetylcysteine, (DL)-Isomer | Acetylcysteine, Monoammonium Salt | Monoammonium Salt Acetylcysteine | Acetyst | Acétylcystéine GNR | Airbron | Alveolex | Bromuc | Azubronchin | Bisolvon NAC | NAC, Bisolvon | Broncho-Fips | Broncho Fips | BronchoFips | Broncholysin | Broncoclar | Codotussyl | Cystamucil | Dampo Mucopect | Mucopect, Dampo | durabronchal | Larylin NAC | Eurespiran | Exomuc | Fluimucil | NAC Zambon | Zambon, NAC | Fabrol | Fluprowit | Optipect Hustengetränk | Hustengetränk, Optipect | Muco Sanigen | Sanigen, Muco | Frekatuss | Jenacystein | Jenapharm | Lantamed | Lindocetyl | M-Pectil | M Pectil | MPectil | mentopin Acetylcystein | Acetylcystein, mentopin | Muciteran | Mucomyst | Acetylin | Mucosil | Mucosol | Mucosolvin | Siccoral | Siran | Ilube | Hoestil | acebraus
Chemical Information
Molecular Formula C5H9NO3S
CAS Registry Number 616-91-1
SMILES CC(=O)NC(CS)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pyrexia08.05.02.003--
Rash23.03.13.0010.000699%Not Available
Rash erythematous23.03.13.029--Not Available
Rash macular23.03.13.003--Not Available
Rash maculo-papular23.03.13.0040.000149%
Rash pruritic23.03.13.0300.000223%Not Available
Rebound effect08.06.02.0090.000669%Not Available
Respiratory disorder22.02.07.002--Not Available
Respiratory distress22.02.01.0120.000372%Not Available
Rhinorrhoea22.12.03.021--
Rhonchi22.12.01.013--Not Available
Seizure17.12.03.0010.000223%
Shock24.06.02.002--Not Available
Skin disorder23.03.03.007--Not Available
Somnolence17.02.04.006; 19.02.05.0030.000223%
Status epilepticus17.12.03.0050.000149%Not Available
Stevens-Johnson syndrome10.01.01.045; 23.03.01.007; 12.03.01.014; 11.07.01.0050.000298%
Stomatitis07.05.06.005--
Stridor22.04.02.003--
Suicide attempt19.12.01.0040.000298%
Swollen tongue23.04.01.014; 10.01.05.015; 07.14.02.0030.000580%Not Available
Syncope24.06.02.012; 17.02.04.008; 02.11.04.015--
Tachycardia02.03.02.007--Not Available
Tachypnoea22.02.01.0140.000149%Not Available
Thinking abnormal19.10.03.001; 17.02.05.023--Not Available
Throat tightness22.12.03.031; 19.01.02.005--Not Available
Thrombocytopenia01.08.01.0020.000223%Not Available
Thrombotic thrombocytopenic purpura24.07.06.014; 23.06.01.011; 01.08.01.0050.000149%
Tongue oedema23.04.01.009; 10.01.05.008; 07.14.02.0070.000223%Not Available
Tremor17.01.06.0020.000149%
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ADReCS-Target
Drug Name ADR Term Target
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