Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Abacavir
Drug ID BADD_D00008
Description Abacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. Chemically, it is a synthetic carbocyclic nucleoside and is the enantiomer with 1S, 4R absolute configuration on the cyclopentene ring. In vivo, abacavir sulfate dissociates to its free base, abacavir.
Indications and Usage For the treatment of HIV-1 infection, in combination with other antiretroviral agents.
Marketing Status Prescription
ATC Code J05AF06
DrugBank ID DB01048
KEGG ID D07057
MeSH ID C106538
PubChem ID 441300
TTD Drug ID D0A4IJ
NDC Product Code 50268-049; 55111-920; 65862-073; 0121-0897; 72865-167; 0904-6874; 70518-1274; 31722-562; 31722-557; 69097-514; 64380-717
Synonyms abacavir | 1592U89 | abacavir sulfate | Ziagen | (1S,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-2-cyclopentene-1-methanol | abacavir succinate
Chemical Information
Molecular Formula C14H18N6O
CAS Registry Number 136470-78-5
SMILES C1CC1NC2=C3C(=NC(=N2)N)N(C=N3)C4CC(C=C4)CO
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
HypersensitivityHLA class I histocompatibility antigen, B alpha chainP01889Not Available11888582; 15016610
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Influenza like illness08.01.03.010--
Insomnia19.02.01.002; 17.15.03.002--
Insulin resistance05.06.02.003; 14.06.02.003--Not Available
Lactic acidosis14.01.01.0020.018890%Not Available
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.008--
Leukopenia01.02.02.001--Not Available
Liver function test abnormal13.03.01.013--Not Available
Lymphadenopathy01.09.01.002--Not Available
Lymphopenia01.02.02.002--Not Available
Malaise08.01.01.0030.028334%
Migraine24.03.05.003; 17.14.02.001--Not Available
Mouth ulceration07.05.06.004--Not Available
Muscular weakness17.05.03.005; 15.05.06.001--
Musculoskeletal pain15.03.04.007--
Myalgia15.05.02.0010.028334%
Myocardial infarction24.04.04.009; 02.02.02.0070.009855%
Myocardial ischaemia24.04.04.010; 02.02.02.0080.004928%Not Available
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Neutropenia01.02.03.004--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Opportunistic infection11.01.08.007--Not Available
Pain08.01.08.004--
Pancreatitis07.18.01.001--
Paraesthesia17.02.06.005--
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Platelet count decreased13.01.04.0010.004928%
Pneumonia11.01.09.003; 22.07.01.003--Not Available
Pruritus23.03.12.0010.056669%
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