Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Gitelman's syndrome
ADR ID BADD_A08653
ADR Hierarchy
03      Congenital, familial and genetic disorders
03.06      Renal and urinary tract disorders congenital
03.06.02      Renal and urinary tract disorders congenital NEC
03.06.02.006      Gitelman's syndrome
14      Metabolism and nutrition disorders
14.05      Electrolyte and fluid balance conditions
14.05.01      Electrolyte imbalance NEC
14.05.01.009      Gitelman's syndrome
20      Renal and urinary disorders
20.05      Nephropathies
20.05.03      Nephropathies and tubular disorders NEC
20.05.03.017      Gitelman's syndrome
Description An inherited renal disorder characterized by defective NaCl reabsorption in the convoluted DISTAL KIDNEY TUBULE leading to HYPOKALEMIA. In contrast with BARTTER SYNDROME, Gitelman syndrome includes hypomagnesemia and normocalcemic hypocalciuria, and is caused by mutations in the thiazide-sensitive SODIUM-POTASSIUM-CHLORIDE SYMPORTERS. [MeSH]
MedDRA Code 10062906
MeSH ID D053579
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Gitelman's syndrome | Gitelman Syndrome | Syndrome, Gitelman | Hypomagnesemia-Hypokalemia, Primary Renotubular, with Hypocalciuria | Hypokalemia-Hypomagnesemia, Primary Renotubular, with Hypocalciuria | Tubular Hypomagnesemia-Hypokalemia with Hypocalcuria | Tubular Hypomagnesemia Hypokalemia with Hypocalcuria | Primary Renotubular, Hypokalemia-Hypomagnesemia with Hypocalciuria | Familial Hypokalemia-Hypomagnesemia | Familial Hypokalemia Hypomagnesemia | Hypokalemia-Hypomagnesemia, Familial | Gitelman's Syndrome | Syndrome, Gitelman's | Potassium and Magnesium Depletion | Primary Renotubular, Hypomagnesemia-Hypokalemia with Hypocalciuria
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Not AvailableNot AvailableNot Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01245Lansoprazole0.001467%
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