| ADR Ontology |
| ADR Term |
Osmotic demyelination syndrome |
| ADR ID |
BADD_A06561 |
| ADR Hierarchy |
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| Description |
A demyelinating condition affecting the PONS and characterized clinically by an acute progressive QUADRIPLEGIA; DYSARTHRIA; DYSPHAGIA; and alterations of consciousness. Pathologic features include prominent demyelination in the central PONS with sparing of axons and neurons. This condition is usually associated with systemic disorders such as HYPONATREMIA; chronic ALCOHOLISM; LIVER FAILURE; severe BURNS; malignant NEOPLASMS; hemorrhagic PANCREATITIS; HEMODIALYSIS; and SEPSIS. The rapid medical correction of hyponatremia has been cited as a cause of this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1125-6) [MeSH] |
| MedDRA Code |
10069350 |
| MeSH ID |
D017590
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ADR Severity Grade (FAERS)
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ADR Severity Grade (CTCAE)
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Not Available
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| Synonym |
| Central pontine myelinolysis | Central pontine myelolysis | Osmotic demyelination syndrome | Extrapontine myelinolysis | Myelinolysis, Central Pontine | Pontine Myelinolysis, Central | Myelinoclasis, Central Pontine | Central Pontine Myelinoclasis | Central Pontine Myelinolysis | Extrapontine Myelinolysis | Extrapontine Myelinolyses | Myelinolyses, Extrapontine | Myelinolysis, Extrapontine | Extrapontine Myelinoclasis | Extrapontine Myelinoclases | Myelinoclases, Extrapontine | Myelinoclasis, Extrapontine |
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| ADR Related Proteins |
| Protein Name |
UniProt AC |
TTD Target ID |
| Not Available | Not Available | Not Available |
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| Drugs Leading to the ADR |
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