Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Telotristat ethyl
Drug ID BADD_D02503
Description Telotristat only approved oral therapy for carcinoid syndrome diarrhea. Telotristat was approved by the FDA in March, 2017 as Xermelo.
Indications and Usage As a serotonin synthesis inhibitor, telotristat etiprate, has the potential to reduce serotonin levels and address the key elements of carcinoid syndrome.
Marketing Status Not Available
ATC Code A16AX15
DrugBank ID DB12095
KEGG ID D09974
MeSH ID C000621725
PubChem ID 25181577
TTD Drug ID D0RE6T
NDC Product Code 70183-125; 11014-0462; 70720-125
Synonyms telotristat ethyl | Xermelo | LX1032
Chemical Information
Molecular Formula C27H26ClF3N6O3
CAS Registry Number 1033805-22-9
SMILES CCOC(=O)C(CC1=CC=C(C=C1)C2=CC(=NC(=N2)N)OC(C3=C(C=C(C=C3)Cl)N4C=CC(=N4)C)C(F)(F) F)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Lymphadenopathy01.09.01.002-Not Available
Lymphocyte count decreased13.01.06.006-
Malaise08.01.01.003-
Mean cell volume abnormal13.01.05.014-Not Available
Mean cell volume increased13.01.05.022-Not Available
Metastases to liver16.22.02.001; 09.04.02.004-Not Available
Nausea07.01.07.001-
Neuropathy peripheral17.09.03.003-Not Available
Neutrophil count decreased13.01.06.010-
Neutrophil count increased13.01.06.011-Not Available
Night sweats23.02.03.006; 08.01.03.031-Not Available
Oedema14.05.06.010; 08.01.07.006-Not Available
Oedema peripheral02.05.04.007; 14.05.06.011; 08.01.07.007-
Pain08.01.08.004-
Pain in extremity15.03.04.010-
Palpitations02.01.02.003-
Pancreatitis07.18.01.001-
Pericardial effusion02.06.01.002-
Platelet count decreased13.01.04.001-
Pleural effusion22.05.02.002-
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Proctalgia07.03.02.001-
Productive cough22.02.03.005-
Protein total decreased13.09.01.004-Not Available
Pruritus23.03.12.001-
Pyrexia08.05.02.003-
Rash23.03.13.001--Not Available
Red blood cell count decreased13.01.05.007-Not Available
Renal failure20.01.03.005-Not Available
Small intestinal obstruction07.13.06.001-
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