Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Telotristat ethyl
Drug ID BADD_D02503
Description Telotristat only approved oral therapy for carcinoid syndrome diarrhea. Telotristat was approved by the FDA in March, 2017 as Xermelo.
Indications and Usage As a serotonin synthesis inhibitor, telotristat etiprate, has the potential to reduce serotonin levels and address the key elements of carcinoid syndrome.
Marketing Status Not Available
ATC Code A16AX15
DrugBank ID DB12095
KEGG ID D09974
MeSH ID C000621725
PubChem ID 25181577
TTD Drug ID D0RE6T
NDC Product Code 70183-125; 11014-0462; 70720-125
Synonyms telotristat ethyl | Xermelo | LX1032
Chemical Information
Molecular Formula C27H26ClF3N6O3
CAS Registry Number 1033805-22-9
SMILES CCOC(=O)C(CC1=CC=C(C=C1)C2=CC(=NC(=N2)N)OC(C3=C(C=C(C=C3)Cl)N4C=CC(=N4)C)C(F)(F) F)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dehydration14.05.05.001-
Depressed mood19.15.02.001-Not Available
Depression19.15.01.001-
Diarrhoea07.02.01.001-
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004-
Dyspnoea22.02.01.004; 02.01.03.002--
Dyspnoea exertional22.02.01.005; 02.01.03.003-Not Available
Eosinophil count increased13.01.06.004-Not Available
Fatigue08.01.01.002-
Flatulence07.01.04.002-
Flushing24.03.01.002; 08.01.03.025; 23.06.05.003-
Frequent bowel movements07.02.04.002-Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Gastrointestinal pain07.01.05.005-
Glomerular filtration rate decreased13.13.01.009-Not Available
Groin pain15.03.02.004-Not Available
Haematocrit decreased13.01.05.001-Not Available
Haematuria24.07.01.047; 20.02.01.006-
Haemoglobin decreased13.01.05.003-Not Available
Headache17.14.01.001-
Hepatic pain09.01.05.005-
Hepatic steatosis14.08.04.005; 09.01.07.003-Not Available
Hypertension24.08.02.001-
Hypoaesthesia17.02.06.023-Not Available
Hypotension24.06.03.002--
Insomnia19.02.01.002; 17.15.03.002--
Intestinal obstruction07.13.01.002-Not Available
Iron deficiency anaemia14.13.02.001; 01.03.01.002-Not Available
Leukocytosis01.02.01.002-
Liver function test abnormal13.03.01.013-Not Available
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