Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Telotristat ethyl
Drug ID BADD_D02503
Description Telotristat only approved oral therapy for carcinoid syndrome diarrhea. Telotristat was approved by the FDA in March, 2017 as Xermelo.
Indications and Usage As a serotonin synthesis inhibitor, telotristat etiprate, has the potential to reduce serotonin levels and address the key elements of carcinoid syndrome.
Marketing Status Not Available
ATC Code A16AX15
DrugBank ID DB12095
KEGG ID D09974
MeSH ID C000621725
PubChem ID 25181577
TTD Drug ID D0RE6T
NDC Product Code 70183-125; 11014-0462; 70720-125
Synonyms telotristat ethyl | Xermelo | LX1032
Chemical Information
Molecular Formula C27H26ClF3N6O3
CAS Registry Number 1033805-22-9
SMILES CCOC(=O)C(CC1=CC=C(C=C1)C2=CC(=NC(=N2)N)OC(C3=C(C=C(C=C3)Cl)N4C=CC(=N4)C)C(F)(F) F)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001-Not Available
Abdominal distension07.01.04.001-
Abdominal pain07.01.05.002-
Abdominal pain upper07.01.05.003-
Ageusia17.02.07.001; 07.14.03.003-Not Available
Anaemia01.03.02.001--
Anxiety19.06.02.002-
Arthralgia15.01.02.001-
Ascites09.01.05.003; 07.07.01.001; 02.05.04.002-
Asthenia08.01.01.001-Not Available
Back pain15.03.04.005-
Blood albumin decreased13.09.01.001-Not Available
Blood calcium decreased13.11.01.002-Not Available
Blood chloride increased13.11.01.005-Not Available
Blood creatinine decreased13.13.01.003-Not Available
Blood glucose increased13.02.02.002-Not Available
Blood magnesium decreased13.11.01.008-Not Available
Blood potassium decreased13.11.01.010-Not Available
Blood pressure increased13.14.03.005-Not Available
Blood thyroid stimulating hormone increased13.10.03.006-
Blood urea decreased13.13.01.017-Not Available
Blood urea increased13.13.01.006-Not Available
Carbon dioxide decreased13.02.01.012-Not Available
Chest pain08.01.08.002; 02.02.02.011; 22.02.08.003-Not Available
Constipation07.02.02.001-
Cough22.02.03.001--
Creatinine renal clearance decreased13.13.01.013-Not Available
Death08.04.01.001-
Decreased activity19.11.01.002; 08.01.01.006-Not Available
Defaecation urgency07.02.04.001-Not Available
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