Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Valbenazine
Drug ID BADD_D02491
Description Valbenazine (development name NBI-98854) has been used in trials studying the treatment and basic science of Tourette Syndrome and Tardive Dyskinesia. In April, 2017, valbenazine was approved by the FDA (as Ingrezza) as the first and only approved treatment for adults with Tardive Dyskinesia (TD).
Indications and Usage For the treatment of tardive dyskinesia in adults [FDA Label].
Marketing Status Not Available
ATC Code N07XX13
DrugBank ID DB11915
KEGG ID D10675
MeSH ID C000603978
PubChem ID 24795069
TTD Drug ID D63WMQ
NDC Product Code 70370-1080; 47049-008; 70370-1060; 66406-0314; 47049-021; 70370-2040; 66406-0274; 70370-2048; 47049-009
Synonyms valbenazine | (2R,3R,11BR)-9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H- benzo(a)quinolizin-2-yl l-valinate | NBI-98854 | Ingrezza | valine 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo(a)quinolizin-2-yl ester
Chemical Information
Molecular Formula C24H38N2O4
CAS Registry Number 1025504-45-3
SMILES CC(C)CC1CN2CCC3=CC(=C(C=C3C2CC1OC(=O)C(C(C)C)N)OC)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Intentional self-injury19.12.01.002; 12.01.08.036--Not Available
Interstitial lung disease22.01.02.003; 10.02.01.033--Not Available
Irritability19.04.02.013; 08.01.03.011--
Lethargy08.01.01.008; 19.04.04.004; 17.02.04.0030.023529%
Lip swelling23.04.01.007; 10.01.05.005; 07.05.04.005--Not Available
Listless19.04.04.003; 08.01.01.0120.002614%Not Available
Loss of consciousness17.02.04.004--Not Available
Malaise08.01.01.003--
Mania19.16.02.0020.003921%
Memory impairment19.20.01.003; 17.03.02.0030.011764%
Mental impairment19.21.02.003; 17.03.03.0020.005229%Not Available
Migraine24.03.05.003; 17.14.02.001--Not Available
Mood altered19.04.02.0070.007843%Not Available
Muscle rigidity17.05.02.005; 15.05.04.0010.007843%Not Available
Muscle spasms15.05.03.004--
Muscle twitching15.05.03.0050.009150%Not Available
Muscular weakness17.05.03.005; 15.05.06.0010.013072%
Myalgia15.05.02.001--
Myocardial infarction24.04.04.009; 02.02.02.007--
Nausea07.01.07.001--
Neck pain15.03.04.009--
Neoplasm malignant16.16.01.001--Not Available
Nervousness19.06.02.0030.010457%Not Available
Neuroleptic malignant syndrome17.05.02.003; 15.05.04.015; 12.03.01.003; 08.05.01.0050.002614%Not Available
Night sweats23.02.03.006; 08.01.03.0310.002614%Not Available
Nightmare19.02.03.0030.015686%Not Available
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Palpitations02.01.02.003--
Panic reaction19.06.04.0030.002614%Not Available
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