Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Valbenazine
Drug ID BADD_D02491
Description Valbenazine (development name NBI-98854) has been used in trials studying the treatment and basic science of Tourette Syndrome and Tardive Dyskinesia. In April, 2017, valbenazine was approved by the FDA (as Ingrezza) as the first and only approved treatment for adults with Tardive Dyskinesia (TD).
Indications and Usage For the treatment of tardive dyskinesia in adults [FDA Label].
Marketing Status Not Available
ATC Code N07XX13
DrugBank ID DB11915
KEGG ID D10675
MeSH ID C000603978
PubChem ID 24795069
TTD Drug ID D63WMQ
NDC Product Code 70370-1080; 47049-008; 70370-1060; 66406-0314; 47049-021; 70370-2040; 66406-0274; 70370-2048; 47049-009
Synonyms valbenazine | (2R,3R,11BR)-9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H- benzo(a)quinolizin-2-yl l-valinate | NBI-98854 | Ingrezza | valine 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo(a)quinolizin-2-yl ester
Chemical Information
Molecular Formula C24H38N2O4
CAS Registry Number 1025504-45-3
SMILES CC(C)CC1CN2CCC3=CC(=C(C=C3C2CC1OC(=O)C(C(C)C)N)OC)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dystonia17.01.03.0010.010457%Not Available
Dysuria20.02.02.0020.003921%
Electrocardiogram QT prolonged13.14.05.0040.013072%
Emotional disorder19.04.02.0050.002614%Not Available
Epistaxis24.07.01.005; 22.04.03.001--
Extrapyramidal disorder17.01.02.0070.003921%
Failure to thrive19.07.05.001; 18.04.01.003; 14.03.02.0080.000682%Not Available
Fatigue08.01.01.0020.128102%
Feeling abnormal08.01.09.0140.040522%Not Available
Feeling jittery08.01.09.0160.013072%Not Available
Flat affect19.04.01.0040.002614%Not Available
Formication17.02.06.018; 19.10.02.0100.003921%Not Available
Gait disturbance17.02.05.016; 08.01.02.0020.047058%
Gastrointestinal disorder07.11.01.001--Not Available
Hallucination19.10.02.0020.011764%
Hallucination, auditory19.10.02.0030.005229%Not Available
Headache17.14.01.001--
Heart rate increased13.14.04.0020.010457%Not Available
Heart rate irregular13.14.04.0030.002614%Not Available
Hip fracture12.04.01.001; 15.08.03.0010.005229%
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypersensitivity10.01.03.0030.018300%
Hypoaesthesia17.02.06.023--Not Available
Hypokinesia17.01.02.0090.002614%Not Available
Hypotension24.06.03.002--
Incontinence20.02.02.004; 17.05.01.006; 07.01.06.0110.006536%Not Available
Infection11.01.08.002--Not Available
Influenza11.05.03.001; 22.07.02.001--Not Available
Initial insomnia17.15.03.005; 19.02.01.0050.002614%Not Available
Insomnia19.02.01.002; 17.15.03.0020.044444%
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